My doctor wouldn't prescribe it to me after my first trimester and I was sick as a dog but it does help
I used it from 5 weeks to 35 weeks when I had my son. I didn't have any issues it was the only way I could hold down food.
My doctor does not prescribe zofran anymore due to its relation with cleft palates. Instead she prescribed me diclegis.
I take it every 3 hours. I don't get the headaches. But even if I did I don't have a choice. I lost 10 pounds on medication and still go in weekly for fluids. I'm 6 months now and finally gained 2 pounds!
Yes its safe. If it wasn't your doctor would not give it...don't worry baby is fine