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Pregnancy (Expert Forum)
Progesterone level ON Ovulation/IUI day
Answered by
Elaine Brown, MD - Pregnancy, Gynecology
Elaine Brown, MD - BLOG
Billings - MT
This forum is for questions and support regarding pregnancy issues such as: Alcohol/Drugs, Bleeding, Caesarean Section , Childbirth, Diabetes, Depression, Fetal Monitoring, Genetic Testing, Hormonal Changes, Labor, Lamaze, Morning Sickness , Nutrition, Parenting, Prenatal Care, Weight gain.
Progesterone level ON Ovulation/IUI day
by redbirds, Oct 12, 2009 08:33PM
I just had an IUI on Fri. morning and have questions regarding my numbers.
On Mon., I had my u/s and E2 levels. showed a few follies, 1 mature. E2 was 908 and LH was 8. Mon night, my OPK's were BARELY starting to get that second line showing.
On Tues, my OPK's were a little darker, but still not positive. I had a ganirelex shot to stave off ovulation (we hope!)
On Wed, had another u/s. Showed 4 mature follies. E2 was 1284. P4 was 1.3. OPK's were much lighter, because of ganirelex. I triggered 9:30 pm.
On Wed pm, Thursday afternoon/pm and Friday after the IUI I had pretty good pressure/twinges/cramping. It was stronger Thurs late night & Fri after the IUI.
Friday, had the IUI at 10:30 am. P4 was 11!
So, Does this progesterone level of 11 on day of IUI mean the ganirelex did not work and I actually ovulated between Wed afternoon & Fri morning? How fast can progesterone levels rise? (it was 1.3, then 48 hours later, 11). Is ganirelex effective if the LH/OPK is already "starting" to fade in but not positive? Are the cramps indicators of ovulation or from the IUI? Will the trigger overpower the progesterone level and still release the mature follicles (if any were left) on Friday (36 or so hours from trigger)? Does the P4 only begin to surge AFTER ovulation, or is there a mini-surge before? (Most of what I've read says after, but 1 article said it can surge b-4)
We are terribly worried about our IUI timing, ovulation and the P4 levels, as I am 37 and have read the older you are, the less time it takes for the egg to disentegrate. We have no known fertility issues (besides working on 15 months to TTC #2. DD is 22 months old), so this is an extra whammy for us. I LOVE information and have scoured the internet for any insight and have not seen anything specifically addressing IUI & P4 levels at time of IUI/ovulation and what all this means to us. Any insight and depth from you wonderful doctors will be GREATLY appreciated! Thank you! G~
On Mon., I had my u/s and E2 levels. showed a few follies, 1 mature. E2 was 908 and LH was 8. Mon night, my OPK's were BARELY starting to get that second line showing.
On Tues, my OPK's were a little darker, but still not positive. I had a ganirelex shot to stave off ovulation (we hope!)
On Wed, had another u/s. Showed 4 mature follies. E2 was 1284. P4 was 1.3. OPK's were much lighter, because of ganirelex. I triggered 9:30 pm.
On Wed pm, Thursday afternoon/pm and Friday after the IUI I had pretty good pressure/twinges/cramping. It was stronger Thurs late night & Fri after the IUI.
Friday, had the IUI at 10:30 am. P4 was 11!
So, Does this progesterone level of 11 on day of IUI mean the ganirelex did not work and I actually ovulated between Wed afternoon & Fri morning? How fast can progesterone levels rise? (it was 1.3, then 48 hours later, 11). Is ganirelex effective if the LH/OPK is already "starting" to fade in but not positive? Are the cramps indicators of ovulation or from the IUI? Will the trigger overpower the progesterone level and still release the mature follicles (if any were left) on Friday (36 or so hours from trigger)? Does the P4 only begin to surge AFTER ovulation, or is there a mini-surge before? (Most of what I've read says after, but 1 article said it can surge b-4)
We are terribly worried about our IUI timing, ovulation and the P4 levels, as I am 37 and have read the older you are, the less time it takes for the egg to disentegrate. We have no known fertility issues (besides working on 15 months to TTC #2. DD is 22 months old), so this is an extra whammy for us. I LOVE information and have scoured the internet for any insight and have not seen anything specifically addressing IUI & P4 levels at time of IUI/ovulation and what all this means to us. Any insight and depth from you wonderful doctors will be GREATLY appreciated! Thank you! G~
Doctor's Answer
by Elaine Brown, MD, Oct 15, 2009 10:49PM
, Oct 15, 2009 10:49PMTo: redbirds
Hi!
I'm not sure that I can answer all of your questions! It sounds to me like your timing was OK. If I understand you correctly you had not ovulated on Wednesday; you triggered Wednesday night, and the IUI was 36 hours later on Friday morning. I suppose it is possible that you ovulated on Thursday, but even so, the eggs can survive for 24 hours, so I think that you are still within the window of opportunity. Also, some progesterone is produced by developing follicles too. I think the only way to know for sure would have been to do an ultrasound Thursday. And finally, I think that probably some of the discomfort was caused by the stretching of the ovaries with 4 large follicles. and some could definitely be caused by the IUI.
I wish you all the best, and really hope that you don't end up with quads!
Good luck!
Dr B
I'm not sure that I can answer all of your questions! It sounds to me like your timing was OK. If I understand you correctly you had not ovulated on Wednesday; you triggered Wednesday night, and the IUI was 36 hours later on Friday morning. I suppose it is possible that you ovulated on Thursday, but even so, the eggs can survive for 24 hours, so I think that you are still within the window of opportunity. Also, some progesterone is produced by developing follicles too. I think the only way to know for sure would have been to do an ultrasound Thursday. And finally, I think that probably some of the discomfort was caused by the stretching of the ovaries with 4 large follicles. and some could definitely be caused by the IUI.
I wish you all the best, and really hope that you don't end up with quads!
Good luck!
Dr B
Member Comments (3)
by 0kids, Oct 15, 2009 05:23PM
i am about to have IUI, what shall I expect?
by zoocrew, Nov 04, 2009 07:30AM
To: Elaine Brown, MD
i have polycistic ovary syndrome and it is very difficult for me to get pregnant i have had one miscarriage and one successfull pregnancy she just turned 10! and well ijust found out i am pregnant..... my beta levels were very low starting out at 1100 then a couple days later 1630 then a couple days after that 2300 not not even a week later they are at nearly 4000 i am concerned at the way people in this proffession can say not viable you will have a miscarriage etc ( i like died inside!) however my drs set me up for another ultrasound in which by the way they only seen and embryo sac when the last beta level was drawn at nearly 4000 my aunt tells me the same thing happened to my cousins wife and they wanted her to take a pill to get rid of the pregnancy............. and she didn't she now hasd a healthy baby boy.............. i am so confused upset and worried,,,,,,,,,, what do my chances look like?
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