I am a healthy, but overweight 36 y/o female with no medical problems and no past fertility issues (I conceived two children on the 1st try at the ages of 29 & 32. In 01/09, I was referred to Endo by OB due to OB blood work-up and fatigue.
On March 4, 2009 I was seen by him and had my initial blood work done that produced these results:
Thyroid Antibodies: Thyroid Peroxidase (TPO) Ab=<10 w/ limits of: 0 - 34; Antithyroglobulin Ab=<20 w/ limits of: 0 - 40
(Siemens (DPC) ICMA Methodology)
TSH = 1.468 w/ limits of: 0.450 - 4.500; T4 = 10.2 w/ limits of: 4.5 - 12.0; & T3 = 166 w/ limits of: 85 - 205
He prescribed Synthroid .1 which I began taking in March 2009. On April 1, 2009 my levels were: TSH = 1.090 w/ limits of: 0.450 - 4.500; T4 = 12.3 w/ limits of: 4.5 - 12.0; & T3 = 164 w/ limits of: 85 - 205.
In May 2009, he increased my dose of Synthroid to .112 and on May 6, 2009 my levels were: TSH = .358 w/ limits of: 0.450 - 4.500; T4 = 10.8 w/ limits of 4.5 - 12.0; & T3 = 154 w/ limits of: 85 - 205.
In July 2009, my levels were: TSH = .147 w/ limits of .450 - 4.500; T4 = 11.9 w/ limits of 4.5 - 12.0; & T3 = 124 w/ limits of 85 - 205. My OB says I may not be absorbing the Synthroid & my endo wants to increase my Synthroid dose to .125. I just want to have one more child.
I had a miscarriage w/ D&C at end of March 09 and a conception w/out implantation 07/09. I have gained 9 pounds since March despite increasing my exercise. My questions are: Does it appear that my thyroid was ever not functioning properly? Can my current thyroid levels be preventing implantation? Is it true that TSH is irrelevant if in treatment for thyroid disorder? Can my low T3 be preventing pregnancy? Will increasing my Synthroid help me achieve pregnancy? If I stop taking the Synthroid, will my thyroid return to normal level of function or is it permanently stalled?
I am pretty confused. It appears to me that your thyroid was within the normal range before they put you on medication. They have now suppressed your TSH outside the normal range. A low TSH means an OVERACTIVE thyroid, not an underactive one.
Also, despite several increases in your dose, your dose is still low.
I can only guess that they are treating the symptoms and not the results.
An overactive or underactive thyroid can both cause problems with ovulation. From your history, you must be ovulating though, or you would not have conceived.
A normal BMI (body mass index) would improve your fertility probably more than synthroid, although, granted it is much more difficult to achieve.
The fact that your anti-thyroid antibodies are negative is good!
Most miscarriages are caused by abnormal development of the embryo due to chromosomal abnormalities. Chromosomal abnormalities are increased in frequency with increasing age. (Reversing the hands of time would help too!)
If you were my patient, I would get a second opinion about your thyroid, and advise you to keep trying!
I hope this is somewhat helpful!
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.