Prostate Cancer Community
Can PSA be 40 with repeated negative biopsies?
About This Community:

This patient support community is for discussions relating to advanced or metastatic prostate cancer, biopsy, bone scan, blood in urine or semen, benign prostatic hyperplasia (BPH), CT scan, cystoscopy, erectile dysfunction (ED), hormone therapy, incontinence, pain (abdomen, lower back or hip), PSA test, prostatitis, radiation therapy, rectal exam, recurrent cancer, screening, staging (tumor size, metastasis), transrectal ultrasound, and urinary difficulty, burning, or urgency (leaking).

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Can PSA be 40 with repeated negative biopsies?

7 years ago at at age 69 I had a PSA of 4.5. Over this time after 4 negative TRUSs  (36 needles) my PSA rose progresively to 35. On DRE I have a nodule at the usual position for cancer.  My prostate is large but causes little trouble in micturation. During this time I have fathered 3 children. Sex is frequent and enjoyable.
After the last TRUS I had a big bleed rectally. Can all these needles have missed a cancer? Should I have more TRUSs.


This discussion is related to PSA Blood Test.
Related Discussions
3 Comments Post a Comment
Blank
Avatar_m_tn

Hi,

Yes the PSA may be elevated and yet there is no detectable cancer. Bear in mind that it is prostate specific not prostate cancer specific. If the prostate is large, then the PSA would be elevated. PSA cannot stand alone to predict cancer being present or not.

There are cases of patients with prostatitis (an infection) which may have PSA values in the 60s level (there is even a report of a man with a level of 103 ng/mL without cancer).

There is some work on variations of PSA, which would involve rate of doubling or speed of the PSA rising. For your case however, these may not be applicable as your levels are already high. There are some tests that are in the works which may be better suited for your case.

Til then, it may be more rational perhaps to look at your symptoms as part of the decision to do anything invasive again.

Stay positive.
Blank
Avatar_n_tn
Thank you!

Lancastrian.
Blank
Avatar_n_tn
My father's psa went from 11 to 33 within 6 months.  He has had biopsies done, all negative.  We are so very worried, but trying to stay positive and prayerful.  Do any docs know the chances of this type of rapid increase in psa and cancer?  He is getting more tests run next week.  Are there specific questions or test types we should require?  Thank you.
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Prostate Cancer Community Resources
RSS Expert Activity
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eating Control: How to St...
Aug 28 by Roger Gould, M.D.Blank