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Prostate Cancer (Expert Forum)
Sudden increase in PSA and Testosterone
Answered by
Ash Tewari, MD, M.Ch. - Prostate Cancer, Robotic Prostatectomy, Urology, Oncology, Surgery
Lefrak Institute for Robotic Surgery and Prostate Cancer
New York - NY
This forum is for questions about: Advanced or Metastatic Prostate Cancer, Biopsy, Bone Scan, Blood in Urine or Semen, Benign Prostatic Hyperplasia (BPH), CT Scan, Cystoscopy, Erectile Dysfunction, Hormone Therapy, Incontinence, Pain (abdomen, low back or hip), PSA Test, Prostatitis , Radiation Therapy, Rectal Exam, Recurrent Cancer, Risk Factors, Screening, Staging (Tumor size; Metastasis), Surgery, Transrectal Ultrasound, Urinary Difficulty or Burning, Urinary Urgency (Leaking), Watchful Waiting.
Sudden increase in PSA and Testosterone
by rpinney, Nov 20, 2008 12:28PM
I'm 53 years old and was diagnosed in 2002 with BPH and low testosterone. Since then the prostate has maintained and stayed smooth but slightly enlarged. I started low dose androgel (1%, 2.5grams) in 02 and my testosterone levels went from 300's to 800's. I cut back to 5days a week and they leveled at the 500 range.
My PSA levels went up slowly from 1.7 to 2.8 in May 2008. Testosterone was 700 at that time.
I just got back from the doctor 11/20/08 and PSA jumped to 6.8 and testosterone 1008.
I'm setting up an appointment with a specialist and will probably end up with a biopsy.
I'm confused because I cannot find any information on sudden increase of PSA and testosterone together.
Any input will be appreciated.
My PSA levels went up slowly from 1.7 to 2.8 in May 2008. Testosterone was 700 at that time.
I just got back from the doctor 11/20/08 and PSA jumped to 6.8 and testosterone 1008.
I'm setting up an appointment with a specialist and will probably end up with a biopsy.
I'm confused because I cannot find any information on sudden increase of PSA and testosterone together.
Any input will be appreciated.
Doctor's Answer
by Ash Tewari, MD, M.Ch., Nov 28, 2008 08:11AM
, Nov 28, 2008 08:11AMTo: rpinney
A PSA test above 4.0 ng/mL should warrant a retest.
The role of testosterone and its relation to prostate cancer is fairly controversial. There is a long held belief that increased serum testosterone increases the risk of prostate cancer. Although a new study shows that pre-treatment testosterone levels had no effect on prostate cancer gleason grade (1).
A repeat PSA and possibly a biopsy would be needed to proceed with any clinical course of action.
Thank you for your question.
Sincerely,
AKT
(1) Sher DJ, et al. Absence of Relationship Between Steroid Hormone Levels and Prostate Cancer Tumor Grade. Urology. Nov 2008.
The role of testosterone and its relation to prostate cancer is fairly controversial. There is a long held belief that increased serum testosterone increases the risk of prostate cancer. Although a new study shows that pre-treatment testosterone levels had no effect on prostate cancer gleason grade (1).
A repeat PSA and possibly a biopsy would be needed to proceed with any clinical course of action.
Thank you for your question.
Sincerely,
AKT
(1) Sher DJ, et al. Absence of Relationship Between Steroid Hormone Levels and Prostate Cancer Tumor Grade. Urology. Nov 2008.
Member Comments (1)
by rpinney, Jan 29, 2009 08:55AM
A related discussion, Am I out of the woods? was started.
