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Prostate Cancer (Expert Forum)
fluctuating psa
Answered by
Ash Tewari, MD, M.Ch. - Prostate Cancer, Robotic Prostatectomy, Urology, Oncology, Surgery
Lefrak Institute for Robotic Surgery and Prostate Cancer
New York - NY
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Doctor's Answer
by Ash Tewari, MD, M.Ch., Oct 03, 2009 11:17PM
, Oct 03, 2009 11:17PMTo: Enforsa
A PSA rising after surgery could be an indication that the disease has spread. A recent Cleveland Clinic study (Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy. J Clin Oncol. 2007 May 20;25(15):2035-41.) Showed that half of their cohort responded salvage Radiotherapy at the earliest signs of recurrence. Furthermore, in the Catalona study (Salvage radiation therapy for prostate specific antigen progression following radical prostatectomy: 10-year outcome estimates. J Urol. 2005 Oct;174(4 Pt 1):1282-6.) At 10 years, the estimate is for progression free survival is 25%. Finally, a recent Johns Hopkins study indicated that men who had a preoperative PSA doubling time of 6 months or less benefited from salvage radiotherapy if it was administered within two years of initial treatment (Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy. JAMA. 2008 Jun 18;299(23):2760-9.).
A reading of the literature would suggest that a PSA response would be expected after radiotherapy in the salvage environment.
Thank you for your question. Best of luck.
Sincerely,
Ashutosh (Ash) K. Tewari, MD
www.cornellroboticprostate.org
This forum is for information only. The contents, such as graphics, images, text, quoted information and all other materials ("Content") are provided for reference only, do not claim to be complete or exhaustive or to be applicable to any particular individual's medical condition. Users should always consult with a qualified and licensed physician or other medical care provider. Users are warned to follow the advice of their physicians without delay regardless of anything read in this forum. The Weill Cornell Prostate Cancer Institute assumes no duty to correct or update the Content nor to resolve or clarify any inconsistent information which may be a part of the Content. Reliance on any Content is solely at the User's risk. This forum may contain health or medically related materials considered sexually explicit. Users are warned that if they may be offended by such Content, an alternate source of information should be found. Publication of information or reference in forum to specific sources such as specific products, procedures, physicians, treatments, or diagnoses are for information only and are not endorsements of the Weill Cornell Prostate Cancer Institute.
A reading of the literature would suggest that a PSA response would be expected after radiotherapy in the salvage environment.
Thank you for your question. Best of luck.
Sincerely,
Ashutosh (Ash) K. Tewari, MD
www.cornellroboticprostate.org
This forum is for information only. The contents, such as graphics, images, text, quoted information and all other materials ("Content") are provided for reference only, do not claim to be complete or exhaustive or to be applicable to any particular individual's medical condition. Users should always consult with a qualified and licensed physician or other medical care provider. Users are warned to follow the advice of their physicians without delay regardless of anything read in this forum. The Weill Cornell Prostate Cancer Institute assumes no duty to correct or update the Content nor to resolve or clarify any inconsistent information which may be a part of the Content. Reliance on any Content is solely at the User's risk. This forum may contain health or medically related materials considered sexually explicit. Users are warned that if they may be offended by such Content, an alternate source of information should be found. Publication of information or reference in forum to specific sources such as specific products, procedures, physicians, treatments, or diagnoses are for information only and are not endorsements of the Weill Cornell Prostate Cancer Institute.
