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Medical Research for a Story
I am writing a story that has a medical disease as one of the main plot points. What I'm looking for is a disease that fits these guidelines:

It must be:

Incurable
Obscure (meaning very few people know about it, not neccessarily that it's uncommon)
Fatal
Able to exist in some impoverished nation
Non-genetic (i.e. able to be transmitted to others)


I'd prefer it to be (but doesn't have to be):

Long lasting (not decades but at least a few years) with severe symptoms for a lot of the duration
Debilitating, at least near the end

Any number of diseases that fit the bill would be appreciated, you don't have to choose only one to tell me
Thank you very much to those who answer
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