Pediatric Zollinger Ellison Syndrome

Our eighteenth month old daughter has been going through her fair share of medical problems. They've found duodenum ulcers, and now her gastrin levels are 200 points higher than the normal high. At our request and her numerous amounts of specialists and doctors they've decided it's best to test her for Zollinger Ellison. Now yes we know how RARE it is in adults and it's not a pediatric disease. However, she was supposed to have an octreoscan, but again because it's not a pediatric test they had to cancel it for the serious complications it could cause if given too much dye. Now were looking for another test, but with all the research I can't find anything. Also, if anyone could give extra insight on what else could cause this issues.

Thank you for all and any of your help!!

[Dr Santos]

Hi,
How is your daughter? I'm sorry to hear about your daughter's medical problems. But can you elaborate on the symptoms and diagnostic tests/ results that she already had? How about genetic tests and family history? Take care and hope to hear from you soon. Best regards.

[Heathmcmi]

Well, she doesn't have Zollinger Ellison, but they're still unsure what she does have. She's still presenting the same problems. They can't seem to get her off her medications:
periactin - used for appetite stimulant - she WILL stop eating w/o it
pepcid - when off of it, her bowels leave a horrible rash on her bottom.

So we've made very teenie tiny strides, but got no further than where we were.

[Dr Santos]

Hi,
Thanks for the update. It is good to know that Zollinger Ellison had been ruled out. Other differentials for this condition in children that comes to mind that may need to be ruled out also are esophagitis, gastroesophageal reflux, gastrointestinal bleeding, gastrointestinal neoplasms, helicobacter pylori infection, malabsorption syndromes, multiple endocrine neoplasia, and even peptic ulcer disease. Although it feels that the previous tests were just tiny strides, I still feel that this has been a step closer in the search for the diagnosis. Hang on and stay positive. Take care always and do keep us posted.