Advair causing burning?

[Babs1176]

I am a 54 y/o fe - non smoker - 145 pounds and excersize regularly
- no prev history of asthma

-last summer diagnosed w/ asthma/hyper reactive airway after experiencing chronic breathlessness.

-all diagnostic tests are WNR(CT,Xray,blood,cardiac)

-PFTs are all well within rage - even better than normal.

-Methocholine challenge VERY REACTIVE to lowest dose-enough so that tech administering test called Dr to get me on meds asap.

-started on advair discus 500 and short course steroids immediately

-repeat problems w/ thrush - NOT an oral hygiene issue - am a dental hygienist and have excellent OH

-switched to advair HFA w/spacer about 6 months ago.

-Somewhere in this - not exactly sure when it began because it was gradual - I began having burning deep in my chest when I breathe.Worse in evenings.

-Had GI workup and am now on nexium 2/day and zantac at night. Baclofen 3x/day and elavil 50 mg at night.(nutcracker esophagus diagnosed)

-missed advair a few times and burning seemd little better. Started up again - yesterday  burning was increased.

-burning REALLY seem to be in trachea - not esophagus. sometimes burning so bad when I do albuterol it REALLY burns. Sometimes  so bad I breathe very shallow

-last week discovered thrush was back - but could only see white patches way back - not on soft palate - felt that *thrush sensation* in trachea On diflucan now

Could I be sensitive to one of the ingredients in advair and that is what is causing burning?

Thanks

[rpete]

A related discussion, chronic thrush in my asthmatic son! was started.

[amy1234]

I also got severe thrush from an enormous amount of antibiotics from pneumonitis caused by an infection from allergic asthma. The Diflucan works really slow. There is a prescription mouth rinse called Nystatin  that you swish around in your mouth for as long as you can, gargle with it and then swallow. It worked for me immediately.  You can even use it in conjuction with the Diflucan. I had to ask my Dr. for it specifically. My mom who is an R.N. told me about it-apparently they use it in the hospital all the time for thrush. The Nystatin also stopped the severe burning from the Albuterol and the Brovana.  I might also advise you to see an allergist.  I found out that I'm severely allergic to several of the chemicals that are in almost all asthma inhalers- I'm glad I saw her first!

[National Jewish Health]

It is possible that the Advair® HFA (fluticasone propionate and salmeterol) Inhalation Aerosol could be acting as an irritant.  It sounds like you have Candidiasis, commonly called thrush, of your upper and possibly lower respiratory tract and it is highly likely that it is due to the high dose inhaled and oral steroids.  If your pulmonary function tests truly are normal or "even better than normal", you need not be treated with this high dose therapy for hyperreactive airways, diagnosed by the methacholine challenge.  Low dose therapy might do the job.

You should have an examination of your throat and larynx, using a fiberoptic laryngoscope.  If you have any sign of fungal infection, the steroids should be completely discontinued and non-steroidal therapy given for the alleged asthma.  Also, if you do have a fungus in your throat, you will also need antifungal therapy.

[teebrd1]

My son is on Advair. Did you realize that you must rinse your mouth after using, and do not swallow after dosing? Advair causes thrush if you do not rinse thoroughly after each use. Ask your local pharmacist he will tell you. Good luck!