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I work in x ray and I know a little bit about PET and Nuclear Med studies. A hot spot is an increase in metabolic activity that attracts what ever radionuclide you had administered before the scan. The entire body will attract it, but the areas of increased metabolic activity will have an increase attraction.....no, something that is benign will not show a hot spot, BUT, that does not mean it is some type of malignancy. It can be any kind of infection and yes, pulmonary fibrosis will show a hot spot!