My husband was exposed to high dose of bleomycin & other chemo agents 8 years ago thru conventional chem and autologus bone marrow transplant. For 7 years has had increased fatigue & SOB with much worsening in symptoms since last summer. Local pulmonologist by PFT result monitoring feels pulmonary fibrosis with COPD-sees restrictive and obstructive components. Husband also exposed to asbestos for 2 years on job 20 years ago. In seeking placement on lung transplant list at a university hospital, further testing done. PFT values somewhat better than previous testing (margin of error?) TLC 60, FVC 58 and DLCO 75. 9 years ago values were above average- 98-104% in most categories. Doc at university hospital says on high resolution CT "minimal subpleural curvilinear lines" also on prone views right worse than left. Bronchoscopy with biopsy showed no bacteria or fungus-only minimal inflammation. Chest xray normal. Patient is very sympomatic-SOB,cough,fatigued,gasping sensation. This is a very enthusiastic,hard working man. Doc wishes to give 3 month window to see if things worsen. He feels most likely not pulmonary fibrosis but is not indicating what he thinks this is. Still wants to redo PFT, CT and to an exercise test in three months. Could you provide insight? This is very confusing. My gut feeling is that something is going on that just cannot be seen. Is this possible?