Non-specific interstitial pneumonitis (NSIP) is one type of interstitial lung disease (ILD). This causes inflammation that leads to scarring of the lungs in the area between the air sacs and the blood vessels. It may be due to toxic fume exposure, lung infection, or connective tissue disease such as arthritis. Most of the time it is not possible to determine exactly what has damaged the lungs. The most common symptoms are shortness of breath with activity and a dry cough. Please read our Interstitial Lung Disease MedFact at http://www.nationaljewish.org/medfacts/interstitial.html for further information. You are welcome to share this information with your doctor.
Steroids like prednisone are frequently the first medicine used. They need to be started early, before the inflammation has become scar tissue. For some people, steroids will help decrease the inflammation so it doesn't become scar tissue. This will cause a dramatic improvement in symptoms as you have noticed with your shortness of breath. However, some people have only slight improvement with steroids. It can take at least 3 months of steroids to begin to see improvement. The response to steroids is related to the type of ILD and the amount of inflammation present. Although the chest x-ray is usually abnormal, it takes a lung biopsy to be certain of the type of ILD. The goal of treatment is that there will be less inflammation or at least no further scarring. This is measured by a follow up chest x-ray, exercise tests, and pulmonary function tests. As soon as possible the steroid dose is decreased to avoid side effects. Many side effects are possible from steroids. Please read our Corticosteroid MedFact at http://www.nationaljewish.org/medfacts/corticosteroid.html for further information about the side effects and their prevention. Talk with your doctor about preventing and watching for these side effects.
Sometimes adding other medicines, like Imuran