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A bullousBullous pemphigoid, close-up of tense blisters is an air-filled, thin walled sac that occurs within the substanceDrug abuse of the lung. When small, such structures are called cysts. Bullae are not very dangerous, but they can cause problems if infected. Also, if very large, they can compress lung and make it non-functional. Bullae are not cancerous but rarely can be associated with cancers of the lung.