Respiratory Disorders Expert Forum
parkinsons/oxygen levels
About This Forum:

This forum is for questions and support regarding lung and respiratory issues. such as: Allergies, Asthma, Bronchitis, Colds - Flu, Chronic Cough, COPD, Cystic Fibrosis, Emphysema, Fibrosis, Lung Abscess, Nasal Polyps, Pleurisy, Pneumonia, Sarcoidosis, Sinusitis, Tuberculosis.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
This expert forum is not accepting new questions. Please post your question in one of our medical support communities.
Blank Blank

parkinsons/oxygen levels

are low oxygen levels a part of Parkinson's disease?  Is this an issue in late stage Parkinson's?
Related Discussions
242588_tn?1224275300
Yes, low oxygen levels can accompany Parkinson’s disease.  Interesting that you should ask this question, as the relationship between the 2 conditions is not widely appreciated.  It has been attributed to 2 phenomena:  
1) reduced chemosensitivity to hypoxia or low oxygen levels, such as decreased responsiveness of the respiratory center in the brain to the hypoxia; and
2) a blunted perception of dyspnea, commonly known as shortness of breath.  The following abstract is an example of such a report.
-----------------------------------------------------------------------------------------------
Authors
Full Name Onodera, H. Okabe, S. Kikuchi, Y. Tsuda, T. Itoyama, Y.
Title Impaired chemosensitivity and perception of dyspnoea in Parkinson's
disease.[see comment].
Comment in: Lancet. 2000 Dec 16;356(9247):2099; PMID: 11145518
Comment in: Lancet. 2000 Dec 16;356(9247):2100; PMID: 11145519
Source Lancet. 356(9231):739-40, 2000 Aug 26.
Abstract Exacerbation of respiratory failure in Parkinson's disease could be the result of impaired perception of hypoxia. We assessed chemosensitivity to hypoxia and hypercapnia and perception of dyspnoea on the Borg scale in 25 patients (Hoehn and Yahr stage 2-3) and 11 controls. Chemosensitivity to hypoxia, but not that in response to hypercapnia, was lower in patients than in controls (0.196 [SE 0.030] vs 0.525 [0.360]; p=0.012); the mean Borg score was lower in patients than in controls under hypoxic conditions (2.9 [SD 1.4] vs 4.8 [2.1]; p=0.0015). Thus, even at an early stage of disease, patients with Parkinson's disease had a subnormal hypoxic response accompanied by blunted perception of dyspnoea.
-----------------------------------------------------------------------------------------------

It could be an issue, especially in late stage Parkinson’s, in that chronic hypoxia could easily go undetected, in both the awake and sleeping states.  In addition, this hypoxia could be aggravated if the person with Parkinson’s had any of the following conditions, which are independently associated with hypoxemia:  
1) any type of chronic lung disease such as chronic obstructive pulmonary disease (COPD);
2) resided at high altitude; or
3) had chronic liver disease.  In addition the chronic hypoxemia could also worsen other conditions such as depression, dementia, or coronary artery disease, commonly called heart disease.

Good luck.
1 Comment
Blank
Avatar_f_tn
Blank
Continue discussion Blank
Blank
Request an Appointment
MedHelp Health Answers
Blank
Asthma Tracker
Asthma Tracker
Start Tracking Now
Blank
Allergy Tracker
Allergy Tracker
Start Tracking Now
RSS Expert Activity
469720_tn?1388149949
Blank
Abdominal Aortic Aneurysm-treatable... Blank
Oct 04 by Lee Kirksey, MDBlank
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank