It would be very difficult to comment on the situation without a definitive diagnosis or even an examination. Other than restless leg syndrome other possibilities that may need to be considered are vascular issues, peripheral neuropathy, musculopathies, hormonal/ endocrine issues, micronutrient deficiencies, infections, stress/ depression etc. Without an evaluation it would be difficult to say what effect would a particular drug have on it. I would suggest consulting an internist, preferable at a university/ teaching hospital for an evaluation and appropriate management.
Hope this helps.
A detailed description of the precise symptoms and a detailed physical examination may help arrow down the diagnosis. In situation there does not seem to be a pattern tests for the more likely possibilities may be ordered for a confirmatory diagnosis.
Hope this helps.
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