Hello, I am a 45 yr old female 2007 I have recurring symptoms swollen with burning at times in knees,fingers, toes, elbows sometimes neck and shoulders I have been taking Prednisone off and on since 2007. Now I take it consistently. My primary has ordered blood test for RA, lupus, ms,gout and other things. All the test came back several times negative for these things.I have recently been seeing a Rheumatologist since 2010 and she also has done a barrage of blood work and xrays that have come back inconclusive. Yet I have had to have fluid drained from my knees that looked like softballs and been given cortisone injections. The blood work only showed that my white blood count was low and that my body was deficient of vitamin D. The Rhuematologist upon first seeing me was certain that I had RA. I was given a regime of Methotrexate 2.5mgs 4 tabs once a week to continue my prednisone 5mgs and increase to 4xaday, Vita D 50,000 units 1 tab once a week,and folic Acid. The x rays only showed that my left big toe showing signs of deformity and thats it, but the third fingers on each hand are swollen and deformed at the knuckles. I am only 45 and this is very frustrating there are days when I can hardly get out of bed I am so tired and when I do I can hardly walk especially when it rains and is cold out doors I only feel comfortable when it is really warm. I am losing hair in patches this is crazy. Any advice or suggestions would be greatly appreciated and helpful.