Dear Doctor,
I've been fighting with chronic prostatitis (at present urethritis) for nearly 2 years. Initially, I had a chlamydia trachomatis + ureaplasma infection treated the standard way (Doxy 2x100mg for 10 days) it all cleared up and 3 weeks following the treatment PCR DNA was negative. 6 months later symptoms returned but as I had a new girlfriend, I retested for everything, chlamydia PCR was negative, only some bacteria were present (enterococcus), I received Doxy again according to sensitivity report. The tratment did not help, I received a bunch of other antibiotics long term with no help. It all progressed to prostatitis. Prostate symptoms are now greatly reduced however urethra is still swollen (opening/tip) and I have some rectal burning sporadically, and pain in the left inguinal lymph node. I did some more testing in several labs (ejaculate for cultivation + urine) - it is clear. I also did blood work - ELISA test for Chlamydia Trachomatis in 2 labs, indicating an active infection (positive IgA, IgG borderline, IgM negative) even though I have been taking ABX that cover chlamydias (doxy, azithro, cipro) long term. Since the antibodies of chlamydia are present, I decided to try combined ABX protocol (Dr. Wheldon's one) - following the 1st (protocol) Doxy again I felt very intense tingling in my urethra/tip that stated 1 h after administration and lasted for most of the day. I continued the multi-abx treatment for 1 month (doxy + azithro + metro), then I switched to Rifampicin, Roxithromycin and Metro. I had a break for 3 weeks and since symptoms returned without ABX, I am now starting Doxy + Moxifloxacin + Metronidazole - suprisingly after I took Doxy today, I have the same reaction - intense tingling in the tip of my penis which lasts for few hours and decreases now. It is no longer happening after next doses of Doxy. I did multiple tests in 2 independent labs, visited a number of doctors (urologists, immunologists) in Europe. What do you think about my reactions to initial doses of doxycycline? This is like a herx reaction confirming the infection I guess. Thank you for your time.