Would the active use of prescriptions used in the treatment of rheumatoid diseases (enbrel, humira, methotrexate, predisone), suppress the creation of anti-bodies and interfere with ability of blood tests to accurately determine a herpes infection?
To my knowledge, no data exist on whether the sort of immunosuppressive treatment you are receiving would interefere with HSV antibody testing. It might depend on the doses of the drugs you are taking, but in the doses normally used for rheumatoid disease, I doubt it would have any effect. Your rheumatologist might have a better understanding of this.
Sorry I can't be more helpful. I'll ask Dr. Hook to take a look at this thread and add a comment if he has more information than I do.
I'll chime in by starting off by agreeing with Dr. Handsfield.
You say little about your situation. If you are worried about herpes but have not had an obvious outbreak, odds are you have not recently acquired the infection. The effect of the drugs that you are taking is more profound on the cellular side of the immune system than the antibody producing side. Furthermore, while these drugs are immunosuppressive, they are not profoundly immunosuppressive. They might make the clinical presentations of herpes more obvious but they would be unlikely to hamper the development of a positive antibody test. If you have not had an outbreak, my advice would be to believe the tests. EWH
Thank you for your responses, they were very helpful.
I've had on-going issues with a irritations and related burning sensations on scrotum, leg creases and anal region since early July. Also a diagnosed/treated e-coli UTI and a 2 weel oral fungal infection treatment. It's been a struggle determining the source and cleaning it up. Lgg type specific test at 16 weeks was negative but immune system issues related to RA is problematic when it comes to health issues and just looking for reassurance as to elimination of potential sources.
Those symptoms don't really suggest genital herpes. Unless you also had been exposed to someone known to have genital herpes, probalby I would not have recommended HSV antibody testing at all. Combining the lack of symptoms that suggest herpes plus the likely reliability of the test result, you can be confident you are not infected with HSV-2.
However, the drugs you are taking could well make you more susceptible to chronic fungal or bacterial infections that might explain your symptoms -- which already was obviously on your doctor's mind, given the antifungal therapy. I suggest you and your rheumatologist (or other primary care provider) continue to follow that path to an ultimate diagnosis. Or see a dermatologist if that hasn't been done yet.
Copyright 1994-2017MedHelp International.All rights reserved. MedHelp is a division of Aptus Health.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.