STDs Expert Forum
HSV-1 and HSV-2 Test report...confusing
About This Forum:

The STD Forum is intended only for questions and support pertaining to sexually transmitted diseases other than HIV/AIDS, including chlamydia, gonorrhea, syphilis, human papillomavirus, genital warts, trichomonas, other vaginal infections, nongonoccal urethritis (NGU), cervicitis, molluscum contagiosum, chancroid, and pelvic inflammatory disease (PID). All questions will be answered by H. Hunter Handsfield, M.D. or Edward W Hook, MD.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

HSV-1 and HSV-2 Test report...confusing

Hi, I just returned from my doctor and received both my HSV-1 and HSV-2 test results. I was expecting only HSV-1 to show positive since I had fever blisters in my mouth while young. However, to my surpise my doctor informed me I was HSV-2 positive and
HSV-1 negative.
I have never had sexual contact and never had symptoms of genital warts, this test was a prerequisite for me and my partner. My question is, did the doctor interpret the results correctly? There is not much info on these results and my doctor seems rather conservative about the issue and unwilling to go into detail about the results.

Here are the results:

Herpes I & II IGG

TEST NAME            Result   Reference Range
HERPES I IGG    NEGATIVE     NEGATIVE
HERPES II IGG   POSITIVE       NEGATIVE

TEST METHODOLOGY - ELISA
LESS THAN 0.90 I.V.     NEGATIVE
0.90-1.1o I.V                  EQUIVOCAL
GREATER THAN 1.10 I.V.  POSITIVE

REFERENCE RANGE FOR HERPES SIMPLEX VIRUS IGG IS NEGATIVE IF NOT EXPOSED


Under HSV-2 "Result", it states positive, but under "reference range" it states negative. What exactly does that mean? The final comment on the test report state that reference range is negative if not exposed. What does that mean?

If I am in fact positive for HSV-2, could it be true that the fever blisters caused in my mouth where in fact the cause of HSV-2?
Related Discussions
300980_tn?1194933000
Although cold sores can sometimes be caused by HSV-2, this is quite unusual.  Most cold sores are due to HSV-1.  I worry that the test you had was not one of the type specific tests such as the HerpeSelect or Captia tests that truly differentiate HSV-1 from HSV-2 infections.  Do you know what brand of test was performed?  Unfortunately, there are a number of tests in use which claim to differentiate HSV-1 from HSV-2 but do so poorly.  In answer to your questions:

1.  A result which is positive is just that.  The so called reference range means that the expected result would be a negative test.  Your test was positive.

2.  See above

What to do.  A couple of suggestions:

1.  Find out what test by brand names was performed.
2.  found out the "Strength" of your positive results.  Usually there is a number associated with it.
3.  Having never had sex, you chances of having HSV-2 are very, very low.  this makes the test results suspect. (BTW, why be tested if you've never had sex?)
4.  The best answer would come from having a viral culture performed the next time you have cold sores and, if the culture is positive, having the virus which is cultured typed.

Hope this helps.  Let me know what you learn about the test you had.  EWH
7 Comments
Blank
Avatar_n_tn
The name of the test was not listed, it just states IGG ABS and ELISA. It was done by Scott and White Reference Laboratory in Temple, TX.

I am unsure of the strength of these results, however I will attempt to obtain them.

I took it to confirm a HSV-1 infection, that is all.
Blank
Avatar_n_tn
I was only able to find out it is manufactured by focus diagnostics and in IGG.
Blank
300980_tn?1194933000
Thanks for checking. The focus diagnostic tests are type specific so I think you need to presume you have cold sores due to HSV-2.  With this knowledge, you can also know that while there is a theoretical possibility of transmitting your infection through kissing or oral sex without a cold sore present, this is quite unlikely.  EWH
Blank
101028_tn?1348750963
Have you ever performed oral sex on anyone to even have been at risk for contracting hsv2 orally?

grace
Blank
Avatar_n_tn
I took the BioKit test and it came up HSV-2 negative. I am almost certain that the lab switched my results for hsv-1 and 2.
Blank
300980_tn?1194933000
Possible although labs don't mess up often. The reason I asked about the "strenght"of your test result is that if the HerpeSelect assay result was in the "low positive" range, there is a possiblity that your HSV-2 IgG test result was false positive.  EWH
Blank
Avatar_n_tn
A related discussion, Interpretting HSV 1/2 IgG Tests was started.
Blank
Continue discussion Blank
This Forum's Experts
300980_tn?1194933000
Edward W Hook, MDBlank
University of Alabama at Birmingham
,
239123_tn?1267651214
H. Hunter Handsfield, M.D.Blank
University of Washington
Seattle, WA
MedHelp Health Answers
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
RSS Expert Activity
242532_tn?1269553979
Blank
How to Silence Your Inner Critic an...
Apr 16 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eaters: How to Silence Yo...
Mar 26 by Roger Gould, M.D.Blank
1344197_tn?1392822771
Blank
Vaginal vs. Laparoscopic Hysterecto...
Feb 19 by J. Kyle Mathews, MD, DVMBlank