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Syphilis sore
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The STD Forum is intended only for questions and support pertaining to sexually transmitted diseases other than HIV/AIDS, including chlamydia, gonorrhea, syphilis, human papillomavirus, genital warts, trichomonas, other vaginal infections, nongonoccal urethritis (NGU), cervicitis, molluscum contagiosum, chancroid, and pelvic inflammatory disease (PID). All questions will be answered by H. Hunter Handsfield, M.D. or Edward W Hook, MD.

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Syphilis sore

How long does it take for a Syphilis chancre to completely heal and/or vanish?

I recently noticed a small sore on the underside of my foreskin and quickly identified it as a probable syphilis chancre. This was confirmed by my doctor, and  a blood test showed that I was syphilis reactive. I just received the single dose [2 injection sites] penicillin treatment 5 days ago, and the chancre has diminished noticably in size & skin-depth, especially in the first few days.

I forgot completely to ask the doctor how long the healing process would take...

Please advise - thanks!!!
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Sounds like it's clearing up on schedule.  Syphilitic chancres usually start to heal within 2-3 days and, if small in size, completely clear up within 2 weeks.  If your sore doesn't heal, it wasn't syphilis:  there is no such thing as syphilis resistance to penicillin.

Good luck--  HHH, MD
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University of Washington
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