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Ureaplasma urealyticum and MYCOPLASMA genitalium???
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Ureaplasma urealyticum and MYCOPLASMA genitalium???

I complained of tingling in the tip of my urethra one year ago, i went to the dr got tested for the usual stds and all were negative and i was referred to the urologist and he stuck is finger up my but and said i had high PSA for prostitis,  given cipro and most but not all symptoms went away.  

i wasn't sexually active for a few months but was in a monogamous relationship and it seemed to trigger the tingling again,  

I did the research this time and demanded other tests,  i tested again for chlamydia, gonn, etc negative and trachamoniasis , negative.


THe last brings me to

MYCOPLASMA GENITALIUM AND UREAPLASMA UREALYTICUM

both these are very high incidents of STD s accross the world, both can cause urethritis and even secondary prostistis this makes total sense!!!!! from my symptoms.  

i have read that it is compicated to diagnose and treat? anyone have experience doing both??? please help??

i read urine PCR tests are most reliable

but as far as treatment i read they are all resistant to the typical azithromycin dose

one responds better to erythromycin and the other moxifloxacin.  

what is the best treatment that would cover both?????????


this has been so frusturating and ihave a new partner and i fear i might of given it to her
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101028_tn?1348750963
not unusual for prostatitis to come back. did they do a manual exam of your prostate when symptoms returned?

grace
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Avatar_m_tn
First of all, you never explain any sexual encounter you think you may have gotten this from, but you say you had tingling at the tip a year ago.  How did that all start?  Second, why do you think your new partner has it?  

You're correct, you will need a PCR test done to determine the mycoplasma strain.  If indeed you have this in your prostate, you will need a prolonger course of antibiotics.  Azithromycin has proven effective for mycoplasma and clindamycine or erythromycin has been effective for ureaplasma.  Moxifloxacin is supposed to be 100% against M. Gen, but I would caution you from using that due to severe side effects.  I know from personal experience that it really shouldn't be used unless you have a life threatening infection, just like it says on the warning labels.  It's pretty harsh.  

Anyway, your first step is to find a good doctor who will listen to you and work with you, and one who will be willing to order the PCR tests for you.  But if it is prostate, then you will need to have prostatic fluid tested.  

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Avatar_m_tn
my dr. is letting me do research he says its out of the scope i just provide the articles, i was given azithromycin zip pack its been 3 days and there is a mild decrease but still a lingering tingling sensation.  

it started when i slept with my ex after she had slept with 5 people unprotected and it was very prevailant  i went to a urologist and after not testing positive for an std i he tested for prostate infection which was eleveated after prostate massage urine test.  

I never felt the prostate was the initial problem i felt it was bacteria moving down to my prostate and as i learn now urethritis from bacteria can be very hard to eradicate and can attack the prostate i feel it more in my urethra but when my prostate was touched that tingly spot in my urethra hurt,  I have no stream problems or prostate pains tho its all a tingle tickle in deep down in my penis. plus the fact that i am 34 in incredible shape makes a random prostate problem unlikely unless driven from a std.  

I did sleep with two girls later in the year as the symptoms decrease if i dont have unprotected sex its like the vaginal fluid brings out the dormate bacteria. or something like that ,  i have had two girls say they had to pee bad and tingle feeling all the time after we had sex they were tested for bacteria levels being nOt right but not specifically for strains.

Im at the point now where i found a speciality lab that i can pay for to identify the strain the PCR can identify the strain but will not show if its MIC antibiotic resistance ,  so a culture has to be done for that with swab, and than an MIC test otherwise you could shoot in the dark forever.  

but thats so expensive 400 total for both.

So i dont know what to do,  i feel that the azythromycin zip backs 500 day one 250 for 4 days are not strong enough to even see?

i get so lost does that help both mycoplasma and ureaplasma?   i seemed to see research of the one day dose has many failing results and that it needs to be like 500 a day for 6 days over a month period??? its so confusing regarding azithromycin

so if symptoms still *(tingle) after this 4 day course of zithromax what should i do?

get those tests as opposed to just randomly firing off antibiotics

I have a new GF that i am so afraid i might of affected her we are going out a week i was waiting for some kind of positive test  before i tell her to treat her we initially had unprotected sex twice and she hasn't complained yet of sensations like i have been feeling.   but that digressing.  i am not having sex with her now im using condoms * is that ok???

any advice guys, this has been a crazy battle

prostate cipro nothing , reoccuring tingly sensation and narrowing it down to the mycoplasma class or ureaplasma class but each can be so difficult to diagnose ! and decide both can be resistant to many antibiotics!!

THE REAL ANSWER IS CEM-101 which is not on the market yet! it has been shown to destroy all of those varieties of bacteria! resistant to other strains!!! crazy i found it but i can use it!!!

this really does cause strife in my life tingly penis is not fun*but i have no discharge, i do not burn on urination but i do feel like urinating often with a tingling tickle about half way down my penis deep inside.  

thanks guys, this is murder to research and docs are really behind the times!!!
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Avatar_m_tn
(to shakentocore)

what if its std that infected urethritis that than affected the prostate??? how to test and treat that????

what drug does both mycoplasma and ureaplasma ??? since you guard against oxi?

the PCR urine test will only show strain but not antibiotic resistance
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101028_tn?1348750963
you have pain, think you might have something but yet you are still having unprotected sex?

many bacteria and viruses that we don't classify as std's can cause prostate issues. your age and overall general health have little to do with it.

azithromycin works longer than 4 days. you need to give it at least week if not 2 weeks in order to see if it helped or not. the dose you are one is quite effective for treating these infections.

follow up with an urologist. at this point you should only be having protected oral and protected sex to protect partners as well as to keep yourself from being exposed to new bacteria that can cause your infection to reoccur as well as further irritate your already existing problem.
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Avatar_m_tn
I thought symptoms were gone until i had unprotected sex than i havent had it after symptoms returned .

Azithromycin ? 2 weeks ? I was only given five days of a dose ??? I found that 500 mg gave the greatest relief on fay one now at 250 its doesnt seem as potent ive read alott of info like 500 3 times a week for 3 weeks ??? Any recomendations there ?

I was thinkin. Two weeks of zithro and a week of moxi to be sure

How will i know when i can have unprotected sex if there are no tests ? To prove it ?

If she has no symptoms should she treat ? To be safe i dnt reinfect myself

Should she get on antibiotics to be sure ? Any advice on how to explain this to her ?
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Avatar_m_tn
Ps does cipro have any effect of both prostate and urethritis ? I feel like a twook zithro followed by other diff biotics could really do the trick for any mutations that survive .
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101028_tn?1348750963
5 days of azithromycin actually works for 10 days.  it's not like regular antibiotics.

don't just keep throwing medications at this hoping something works. give this one a chance.

also don't allow yourself to get obsessed over something this "might" be. if symptoms reoccur after this treatment, return to the urologist for further follow up.
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Avatar_m_tn
Hey man, sorry I never responded, I've been busy and haven't logged on.  A couple things I want to say right off the bat.

1.  Try to chill out and not get too worked up.  I know this is easier said than done because I've been and am in your shoes, but try to stay level headed and work through your problem systematically.  It may take some time to figure this out, so be patient.

2.  Grace is correct, no unprotected sex of any kind.  It's safest for you and your partner.  

To address the questions you asked me:

If it's bacteria that infected your urethra and then moved to the prostate, you will need a longer course of antibiotics to treat it, as I said earlier.  Antibiotics do not penetrate the prostate well due to the blood barrier, so it requires longer treatments to keep the drug in your system longer and allowe penetration into the prostate.  Again, you must get proper testing to figure out what will work.  You should start from the beginning with a urine test for Chlamydia and culture for other bacteria that could be a causative agent (strep, Staph, etc.).  You should also have a Gram Stain done to verify the presense of white blood cells (Gram Stain is better than urinalysis).  If nothing shows up in any of those tests, you should move to a PCR for the less likely suspects (UU and M. Gen) on a urine or swab sample.  If those do not show anything and your doctor gives you a prostate exam and find it's boggy or soft, then you should move to culturing and testing prostatic fluid.  

The point, you need to find the source.  If it's localized in your urethra and genital tract, then you can treat with a normal course of antibiotics.  If there is nothing there and the prostate is affected, then a longer course of Abx will be required, as well as trying to determine the causative organism so you're sure you're using the correct abx.  I know you were given Cipro, but it's not that great against Chlamydia and some strains of Gono, and it's not good at all against UU and M Gen.  Moxiflox is supposed to be bullet proof, but again, I'm warning you that it should be used as a last alternative.  If the Azithromycin isn't helping, talk to your doc about an extended course of Doxycycline.  Also make sure you get treatment for Trich at the same time (preferably a 7 day course of Metronidazole or single dose of Tinidazole).  Doxy is highly effective for the prostate, produce high syrum levels in the body that allow more of it to penetrate the prostate.  An extended course of Erythromycin may also be worth a shot if Doxy doesn't help.  If no abx is working and you cannot find any causative organism, try moxifloxacin, as it's the atom bomb of abx, and hope you can tolerate it.  Good luck to you brother, and please let us know how things are going and what you find out after further testing.  persistent cases of ngu are very perplexing it seems.  Feel free to message me any time as well.  
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Avatar_m_tn
this is what i noticed, the day i took 500 mg, there was the biggest effect the days 250mg were ingested were the doorment days, and things just lingered

i finished the course with a 60 % removal of symptoms the rest symptoms linger.

I talked to the dr. i read more info in research and other drs that say zithro should be treated either for 9 days * in this situation where it is a long time infection.

or for 3 weeks with a 3 time a week dose.

i got just a few more days of 500 mg and each time i take them there is now another 20 % reduction of symptoms that were not happening with the 250 mg dose

* i know i am on the right track but i have to make sure i get the complete eraication of this and i dont think zithro is going to take me there

I think the best thing will be a course of moxi after this to destroy it.

any recommended dosages of moxi????? im possitive that will eradicate the final 20 %

PS

my GFs symptoms have now manifested with a urinary tract infection
i guess zithro will be her start i hope she doesn't need moxi
i kinda want to go with her to the emergency room as her GP is gone for the week.  you think i can explain this to them at the emergency room.?
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Avatar_m_tn
NOTE TO ALL,

I conveyed the importance to my gf to go get seen, but her schedule prevented her from going to the drs.  Until sat night when her symptoms manifested like an atomic bomb, she had burning with urination, headache, chills, fever and abdominal pain.  

The drs in the ER refused to listen to me about my being the one to infect her the whole ureaplasma mycoplasma connection was not listened to at all.  she was given standard treatment of cipro * which i had direct contact with labs to say the cirpo Cipro is a quinolone that acts mainly on gram-negative bacteria. Mycoplasmas and ureaplasmas are derived from Gram-positive bacteria and cipro does not have much activity against them. Which frusturated me, her symptoms contineud to get worse

Meanwhile my symptoms are 80% gone with the zithromax, but i think im gonna end up going to an infectious disease specialty and taking moxifloxacyn but i dont know if i am completely clear ? since testing is so difficult? and how about her???????  
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Avatar_m_tn
PS.  THe lab told me if i have taken antiobiotics the pcr tests most likely will read False negative???? is this true?
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Avatar_m_tn
Also my gf came down w
A horrible uti stomach pains and chills and a horrible eyes swelling infection app after our unprotected sex encounter .  They refused to make a connection w me at the er and refused to listen about ureaplasma . But it just has to be related to my infection !
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101028_tn?1348750963
what testing did they do on your gf? did they take urine , do a pelvic exam and take cultures from her cervix?

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Avatar_m_tn
Based on what you are saying about your GF, it's imperative she been seen and have a pelvic exam by a gynocologist, not the ER.  ER doctors are not used to dealing with these issues and may be lacking in knowledge.  Try not to inject your own opinions about MG or UU, just make sure she gets that pelvic exam ASAP.  It sounds like you're describing symptoms of Pelvic Inflamatory Disease, which can affect her fertility if left untreated.  I do not know why the ER gave her Cipro.  It's typically used for UTI's, but it doesn't sound like they did any testing with her to verify typical UTI causing bacteria.  They should have at least considered the fact that you've been on Zithromax and are being treated for STD type symptoms.  

No one can say if it's related to your infection, but it sounds like you're doing the right thing by continuing your treatment with Zithro and following up with an ID Doc.  My ID doc was not very knowlegable about these kinds of things, but he suspected what your doctor did, that I had a long standing infection, and standard abx treatments would not work, so he put me on an extended course of abx.  Most of my symptoms have cleared up, but I still have some that I may end up living with.  Who knows, the point is, please follow up with an ID Doc.  
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Avatar_m_tn
this is a nightmare GF said goodbye! adios , she didn't understand the bacteria thing and blamed me for everything .  It was a new relationship i was in love with her and like that its flushed down the toilet.

Might i add that this is the second girl in a year period to come down with the same symptoms it has to be me.

I cant even reach her to get her the right treatment they cultured out the bacteria and such and did a gyno er exam.  I still dont think gynos know how to treat this.

Im so lost im gonna see the ID dr on friday but ive learned about the limitations of these drs.  

There are no accurate tests once you ahve taken antibiotics you need to be clear of them for 3 weeks.  

I did howver find the top lab on the subject that uses a different form of blood dna amplification diff than any one else that can test for multi species. even if i find the bug

Its still hard to treat, the blood supply in the prostate urethra is very low and getting high levels of antibiotic in there is difficult. im afraid another antibiotic is just gonna make a super strain within me.  

there are this china guy that contacted me from an email and he says to be completely treated the devloped direct injection techiniques in china and it costs 17 thoushand dollars !!!! for 30 days they are seriously taking advantage of this disaese (disease)

there are tons of holistic approaches to urethra profusion treatment etc.  


What is a good strong dose of moxifloxacin??? i think maybe a suppository antibiotic might be better?/ what do you think?

lost , crushed over losing my gf, and still battling ....
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Avatar_m_tn
Hey man, hang in there brother and don't get sucked into all these expensive treatements.  You're correct, doctors have their limitations, so you need to be proactive and do your own research.  Like I said, find someone who will work with you and help you, and not try to convince you that you're crazy.  

Regarding moxiflox, I don't recommend it but if you're going to take it, the dose is 1 pill daily and the duration is 7-10 days.....I hope you can make it that long.  I made it eight days on Moxi and thought I was going to die on day 8 so I had to stop.  There are also many restrictions on foods that you should not eat so many hrs prior to or after taking a dose.
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Avatar_m_tn
what other fluqonone antibiotic would you recommend?

How can i ever know that i am free and clear???? to not have protected sex? * in a long term realtionship of course.


it looks like the GF is gonna take me back, what should i have her check for???

i just dont know how to know we are not contagious?
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Avatar_m_tn
Hi Greensky,
I have suffered from NSU/NGU in the states for two years now and tried all the meds.
I am seeing another consultant on Tuesday who I have seen before but told me to live with it.Which I will not accept.
I know there are people on here who seem to have been told that it is not contagious but I have never been told by the clinic or my Urologist that it is not.
They say practice safe sex all the time but twice over the years I have split condoms so where do you go from there if that happpens in the future.
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Avatar_m_tn
Well i saw the ID dr he  practically laughed at me uu myco ? Unlikely and if so cipro would cure it ! Siggghhh i felt .  and said there is no infection . Im
Left having tO treat myself , i know im contagious and i can still feel it lingering . I feel like waiting to see if it goes away is stupid i feep like one more treatment either moxi of levaquin ? I might have to order online ???? Ur thoughts guys ? Im not gonna call myself fine because the dr doesnt understand after the antiobiotics im gonna do a holistic approach than test the dna tests .
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Avatar_m_tn
Hey man, try to stay positive.  I know it takes over your life but keep your head up.  

Regarding your girlfriend, please have her get a pelvic exam and explain to the gyno that she may have been exposed to an STD.  The doctor should know what to test for from there.  Try not to influence her with the UU and M Gen, just let her deal with her doctor.  

Regarding yourself, I always recommend people get treated for Trich with Metro or Tindamax.  If you're going to go with a quinolone, Moxi is supposed to be the most potent.  If your doc isn't willing to listen to you, move on to another and find someone who will work with you.  I can't state that enough, find someone who will work with you.  

I have heard LionsKipper's story and I hope you don't have to deal with what he is going through, but you should continue to have protected sex until you get this worked out, just like he is.  Maybe you should hold off on any more antibiotics and begin your holistic approach, and then you can get tested for UU and M Gen.  If I were you, that would be the route that I would go.  No need to take Moxi when you don't have to.  Your GF knows about all this, so there is no reason for you to rush into treatments that may do more harm than good.  Go get your PCR done and figure it out from there.  
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Avatar_f_tn
HEY Greensky1977  
I am also suffering with same for the past 3months
let me know your progress
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Avatar_m_tn
well my symptoms seem completely gone her eye is about 85% gone,  what tests can we both get to make sure we are ok? i dont think they will let me get the blood dna amplification multi species bacteria test1!!!

upon further review it could of very likely been related to silent chlamydia, which would make sense since she got a horrible eye infection.

i dont know what to do to finalize this or when we will both be able to have unprotected sex again.  

my prostate was examined there was no pain, tingling has gone away, she has no burning on urination her eyes is almost healed.

what tests can we get, urine? blood? *i think swabs are very hit or miss!

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Avatar_m_tn
Hi,

I've been having the same symptoms as you for over 8 months now.  I've been on 200mg doxy (10 weeks), rocephin, 500mg cipro (4 weeks), 800mg bactrim ds, 2g flagyl (once), 1g Zithro (once), 500mg levaquin (4 weeks) and now 1g of Tindamax for 7 days. I've taken several standard std tests (while taking the antibiotics) as well as a PCR Trich and mycoplasma/ureaplasma test ($150).  All have come back negative but I'm still having prostrate pain mainly after having the tingling in my urethra originally like you described.  I feel it's either bacteria or a parasite that's lodged in my prostrate but all tests are coming back negative.  One thing I've read about the STD and PCR tests is that you have to be antibiotic free for 4 weeks otherwise it will effect the results.  Also, the first morning urine is the best to use.  My uro didnt' tell me any of this nor has he done a prostrate massage for a 4 glass test to culture.  It's just pee in a cup and "everything looks clean".  I've become a human dart board for antibiotics which has helped temporarily but eventually the pain and urination issues come back.  How much zithro did you wind up taking and how long was the treatment?  I've read 4.5 grams for 3 weeks (500mg every 3 days) is best for NGU, mycoplasma/ureaplasma.  did you try an extended course of tindamax or flagyl?  what about the moxi?
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Avatar_m_tn
Hi,I visited the Gum clinic last tuesday and spoke with the consutant there
for quite a while regarding all this.
He checked my prostate all ok.Took a swab from my penis.Good news nothing at all could be seen.I told him that I still feel symptoms and he said with all the treatment I have had I am uninfectious.
Next stage he gave me an emollient to wash with rather than my shower gel.
lubricant for masturbation.
anaesthic gel for tip of penis.
If they do not work he give me a steroid gel to use.
If they do not work he said he has another tablet to try and may send me for hypnosis as he thinks I am suffering from a lot of anxiety.
So far still feel the same and will start on the steroid.
Maybe this is a residual side affect from my Nsu but I still am having symptons.
I will have to see what happens and let you know.

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Avatar_m_tn
Saw this thread and had to post. My story is up on the expert board now. Similar to a lot of your stories and I am freaking out in the same way a lot of you are. Nearly a year in and no improvement. I asked Dr. Hook about m. gen. stuff and am waiting for a reply. Please continue posting updates for better or worse.
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Avatar_m_tn
My daughter has had years of torment with cystitis, burning on urination and vulvadynia but all tests came back negative - she went to many different drs - urologists, gynaecologists and internists and even tried nutritionists and healers. Finally she came back to Uk in desperation - she lives in California - and was diagnosed with ureaplasma - the test was negative in US but positive here as it's a difficult one to do. She has just started taking a very high dose of doxycycline (600 mg) for 10 days as lower doses sometimes don't work and she doesn't want to take any chances after suffering for so long. These bacteria are very resistant. Will let you know if it works....fingers crossed!
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Avatar_f_tn
Hi Greensky (or anyone else who can help),

I just came across your post from last year regarding Azithromycin and ureaplasma treatment.  Based on your post, it sounds like the antibiotic eradicated your infection, which is great news!  My partner is having similar symptoms, and the dr. has put him on doxycycline 2x a day x 14 days.  He started taking them last Tuesday, but this past weekend, he had burning on urinating, and a tingling sensation which he believes is in his prostate.  Wanted to check in and see if your symptoms have completely gone away from Azithromycin, since it's been a year (and would you recommend it?), and if you were able to resume sexual activity with your partner without any further problems (did she have to be treated with Azythromycin also?).  If so, what dosage do you think worked best for you?  We are beyond frustrated, and at our wits end with all of this - looking to speak with dr. about further treatment.  

Any input you can offer would be GREATLY appreciated. Many Thanks!
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Avatar_f_tn
For those searching for a lab that does Mycoplasma genitalium tests (and at a decent price), check out the Mycoplasma lab at the University of Alabama-Birmingham. Here's a link to their site:

http://www.mycoplasma.uab.edu/

I spoke with the lab manager, Lynn Duffy, whp was extremely helpful. It requires a doctor to order the test, and my primary care physician and urologist each refused because neither had any clue what M. Genitalium was. I have an appointment with an infectious disease doctor in three weeks, after I try the z-pack. I've already tried doxy and levaquin w/o success.
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Avatar_m_tn
I have the samething...  I did a dna test i show postive mycoplsma in Urine and semen...  My symptom are better but not gone...  How can we no for sure we are not contagious.  I dont want to give that to nobody!!!  

Now im on a month of doxy hopeffuly that can take the pressure i have in prostate!!!  That thing is a nightmare!!!  

As if they are not testing for this!!!

Anybody tried dr.Bahn in California!!!  Direct injection

Im lost i need closure for this thing
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Avatar_m_tn
Does anyone know if the absence of white cells in a gram stain/urethral swab test rules out mycoplasma and urea plasma? After one unprotected sex encounter in September I developed a discharge, slight irritation and some dribbling after peeing. Been tested 5 times now for chlamydia gonnoreah syphilis and herpes, all negative. Every time, there have been no cells so I am told I just don't have an infection.

I am worried it might be mycoplasma or urea but the NHL clinics don't test for these. As they are bacterial infections and I believe that it is the presence of white cells in the swab tests which indicates such an infection, is it possible that I have either mycoplasma or urea plasma or would 5 negative gram stain tests make this impossible or at least highly unlikely?
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Avatar_f_tn
Guys, I'm currently having fever, sore throat, headache burning eyes, quite sore but most of all i have been feeling exhausted and yet i feel very awake and numb . My bf and I have been together for 4 years. Last year he had unprotected sex with someone else. After that he started dripping for days which NEVER happened to us. They both got their std tests and both came out negative although the girl's results came out with a flu like virus. We didnt have intercourse for almost a year just oral..nothing. I just noticed that I would get a sore throat from time to time. But .just 2 weeks ago we had unprotected sex and now he's dripping again I'm ill. Anyone with the same experience ? Thank you . Awaiting your feedbacks...
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Avatar_m_tn
You need to get checked for Urea Plasma Genitillium. I had your symptoms for a few years - my ex-hubby was sleeping around. Had the test run in Vegas - most gynos dont run them. Came back positive, had a 10 day course of Doxy and was good to go until a condom broke with an unsignificant other. Same symptoms immediately - itching, burning, discharge, urinary tract infection, burning eyes, sore throat, fatigue - went for battery of tests, all neg. Finally found a doc to test for Urea - sure enough, positive. Day 10 of Doxy and feeling better.
DO NOT have unprotected oral sex - I am convinced it is transferred that way too. Good luck and hand in there - get a good dose of Doxy and Metro (vaginal) that should do the trick -
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Avatar_m_tn
So what course and med worked for you? I think I saw the Zithro but not certain - thank you!
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