STDs Expert Forum
Urethral discharge; negative PCRs
About This Forum:

The STD Forum is intended only for questions and support pertaining to sexually transmitted diseases other than HIV/AIDS, including chlamydia, gonorrhea, syphilis, human papillomavirus, genital warts, trichomonas, other vaginal infections, nongonoccal urethritis (NGU), cervicitis, molluscum contagiosum, chancroid, and pelvic inflammatory disease (PID). All questions will be answered by H. Hunter Handsfield, M.D. or Edward W Hook, MD.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
This expert forum is not accepting new questions. Please post your question in one of our medical support communities.
Blank Blank

Urethral discharge; negative PCRs

3.5 weeks ago protected vaginal sex with a sex worker.  I passed out afterwards and do not remember removing the condom. I did not clean myself until the next morning. The next day I was uncomfortable above my pelvis/ bladder.

5 days later I was tested for 7 STDs by urinary PCR . I got 1g azithromycin/ceftriaxone im.  Results -ve

The pain persisted.  After 14 days  (10 days post medication)  I saw a urologist. U/S of prostate and bladder were normal. Urinalysis;3-5 pus cell / HPF ; 4-6 RBC / HPF; +ve for mucus strands. Another PCR test from a urethral swab (after prostatic massage) was sent to the UK. I got 7 days of cipro (500mg SID) + 14 days doxy (100mg BID)

PCR Results for Chlamydia, Gonnorhea (Gonorrhea), Mycoplasma, ureaplasma, Herpes, Gardenella and trichomonas _ve. Urine culture after 48 hrs -ve.

The pain persists. I have urgency to urinate, a burning / tight feeling above my pubic bone. I have noticed a mild clear discharge in mornings over last few days (4weeks post exposure).

my questions are ;
• Can I trust the post prostatic massage urethral swab PCR test sent to UK bearing in mind I had received medication 10 days earlier ?  I was still symptomatic when the urethral swab was taken.

• Can I consider myself safe to my wife for these 7 STDs (other than herpes I know) based on the negative results ? I have informed her of the incident but not the symptoms of pain.

• What are the other potential causes of the elevated WBC and RBC in the urine if not due to some sort of STD infection ?

• I am aware that in a good proportion of cases no cause is found for NSU. What does this mean for prognosis and also risk of passing on some unknown pathogen ?

Medication wise; where do I go from here ?
300980_tn?1194933000
Welcome to our Forum.  I'll try to help.  The exposure you describe was condom protected and therefor safe sex.  Further, your symptoms began a day or two after your exposure- sooner than occurs for any STI.  You now have negative tests and have been treated on more than one occasion for possible STIs even though your tests are negative.  It is time to move on.

Let's work through your questions:
• Can I trust the post prostatic massage urethral swab PCR test sent to UK bearing in mind I had received medication 10 days earlier ?  I was still symptomatic when the urethral swab was taken.

Yes, the result indicates that either you did not have an infection or, if you did, that the infection you had has been successfully cured.  If your symptoms had been due to an STI, the tests would have been positive.

• Can I consider myself safe to my wife for these 7 STDs (other than herpes I know) based on the negative results ? I have informed her of the incident but not the symptoms of pain.

Yes, it is safe to have unprotected sex with your wife.  

• What are the other potential causes of the elevated WBC and RBC in the urine if not due to some sort of STD infection ?

A small amount of WBC or RBC can be normally present in the urine.  Other problems such as kidney stones can cause some of these problems as well.  You have no evidence fo having an STI of any sort despite your continuing symptoms.

• I am aware that in a good proportion of cases no cause is found for NSU. What does this mean for prognosis and also risk of passing on some unknown pathogen ?

In persons with persistent, pathogen negative urethritis, there is no evidence that there is risk of infection for sexual partners.

Medication wise; where do I go from here ?
I owuld not treat further.  It is time for you to move forward and not worry further

I hope these comments are helpful. EWH
2 Comments
Blank
Avatar_m_tn
A related discussion, Prostate was started.
Blank
Continue discussion Blank
This Forum's Experts
239123_tn?1267651214
H. Hunter Handsfield, M.D.Blank
University of Washington
Seattle, WA
MedHelp Health Answers
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
RSS Expert Activity
469720_tn?1388149949
Blank
Abdominal Aortic Aneurysm-treatable... Blank
Oct 04 by Lee Kirksey, MDBlank
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank