There is over a life time a loss in brain tissue in these areas in schizophrenia and bipolar as recent research has noted. However this effect can also occur and more markedly so in long term neurological disabilities that specifically effect and cause deterioration in brain functioning and tissue loss. It would depend on what the specific diagnosis is as to what the follow up would be. A ct scan and an mri are helpful in noting what might be occuring and how to treat it although only a doctor would understand the clinical specifics.
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