I have had a sleep problem for the past two years. It started with body temperature discomfort, then progressed to night sweats and hot flashes, although I had been comfortable on ERT for 14 years. Because of a CLL diagnosis I had to go off estrogen. The hot flashes were intense and nearly hourly day and night so I went back on ERT. Of course by then my sleep patterns were much worse. My hot flashes are now looked after by the ERT but the sleep problems aren’t. I have been on Zopiclone for the past 7 months; am now taking 5 mg at bedtime and 5 more mg in the middle of the night. I still wake up 6-8 times in between, never getting more than 2-3 hours at a stretch, am exhausted and moody. In January my PCP started me on Effexor XR and he wants to double it to 150mg help boost norepinephrine. I had a hard time with nausea when I started it and hesitate. What do you think would help me sleep? I feel restless and jiggly during the day, and jittery in the evenings until I take my Zopiclone at bedtime. Since on Zopiclone I also have problems with frequent "hypnic jerks" that wake me up just before dropping off. It's frustrating. Could this be related to the Zopiclone?