Yes, this thought process can be a sign of depression if it is persisting after a period of time. Relationships do see their ups and downs, and when you hit a rough phase with a friend you may feel as though you are losing him/her. However, these feelings are transient and go away after talking things out. If these feelings persist, they can be due to depression. Talk to your family doctor, and if there is a need, go for counseling. Take care!
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