Thyroid Cancer / Nodules & Hyperthyroidism Expert Forum
Can you be allergic to synthroid?
About This Forum:

Questions in the Thyroid forum are answered by Mark Lupo, MD. Topics covered include Goiter, Graves Disease, Hyperthyroid, Parathyroid/Calcium Problems, Thyroid Cancer, Thyroid Nodules/Cysts, Thyroiditis, Thyroid & Pregnancy, Thyroid Stimulating Hormone (TSH), Thyroid Tests, and Thyroid Surgery.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
This expert forum is not accepting new questions. Please post your question in one of our medical support communities.
Blank Blank

Can you be allergic to synthroid?

I was diagnosed with Hashimoto's in 11/05. At that time my results were TSH-7.23 T4, Free-.8 and Thyroid peroxidase aby 172.  I had gone to the doctor because I was having these spells that would include stomach going crazy, chest pain, nausea, headache, heart fluttering, sweating, muscle weakness(felt like I could barely walk), arms and wrists felt numb.  I was having one of these spells about twice a week and had gone to the emergency room twice thinking I was having a heart attack.  She started me on synthroid 25 mcg and within days all of my symptoms were much worse.  After 2 weeks my dose was raised to 50 mcg and things were even worse, I couldn't vaccum a room, push a grocery cart, drive a car because I was so weak.I have had 2 stress tests on my heart and been tested for lupus, rheumatoid arthritis, lyme disease and any other test the doctors can think of and everything comes up negative except the thyroid tests. I went off the synthroid after about 6 weeks and after a few days I felt fairly normal again.  This lasted a few weeks and then the spells began again and I was put back on synthroid 12.5 mcg and then raised to 25 after a few weeks and I felt like I was on some kind of speed.  During this time I had seen several different doctors to try to figure out what was wrong with me and they keep diagnosing anxiety, panic attacks and depression and want me to go on Prozac.  Well these do not feel like panic attacks and I am not depressed, I am frustrated and irritated that no one can figure out what is wrong.  I have not been to work in 4 months because I feel awful.
Related Discussions
97953_tn?1193367871
Doubt it's an allergy - you may be sensitive to thyroid hormone.  Would stop it for 4 weeks and retest TSH/T4/T3 and if clearly still hypothyroid re-challenge with another brand to ensure you weren't sensitive to one of the fillers in synthroid.

Also, ask the docs to test for pheochromocytoma-- screen with plamsa free metaneprhines.
3 Comments
Blank
Avatar_n_tn
Some people (a small number, I believe) have anxiety and other distressing symptoms when they try to take T4.  This reaction is to T4, not to Synthroid specifically.  I know this because I was one of those people.

Without going into great detail here, you can read the history of my illness by downloading this file:

ftp://ftp.ucar.edu/era/ThyroidTale.htm

I'm much better than I was, but still not completely back to normal.  The bottom line was, I had thyroid antibodies which were caused by the consumption of gluten.  Once I got off gluten grains, my antibodies eventually went to zero.  After I had gotten rid of the antibodies, I found I no longer had anxiety when taking Synthroid in reasonable doses.  (I'm currently on 88mcg daily.)

Right now, I'm working on anxiety obviously caused by Cytomel.  I believe that getting rid of the antibodies improved my body's ability to do peripheral T4->T3 conversion, and that the T3/T4 therapy I've been on for so long, may be both unnecessary and counterproductive.  This is, of course, a hypothesis; few docs (including endos) seem to be knowledgeable about the connections between HAIT, anxiety reactions, and peripheral conversion.

However, thyroid treatment really is an art, so who knows where I'll end up.  I'm beginning to think that doing it by the way you feel, rather than the tyranny of the lab test, may be the way to go.

I strongly believe, as the result of this experience, that low antibodies over a long period of time, can do just as much damage as high antibodies over a short period of time.  I strongly suggest that everyone who has an autoimmune disorder, should have  tests (e.g. ELISA) to rule out food allergy as a cause.

Blank
Avatar_n_tn
i'm pretty sure i'm having a reaction issue with synthroid. i was overdosed on cytomel and am just starting to introduce a higher dose of synthroid back into my system.  i would love to read your article, but keep getting an error page when trying to open.  is there another link to get to it?
Blank
Avatar_n_tn
A related discussion, Reaction to Synthroid was started.
Blank
Continue discussion Blank
This Forum's Experts
97953_tn?1193367871
Mark Lupo, M.D.Blank
Thyroid & Endocrine Center of Florida
Sarasota, FL
MedHelp Health Answers
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
RSS Expert Activity
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eating Control: How to St...
Aug 28 by Roger Gould, M.D.Blank