Thyroid Cancer / Nodules & Hyperthyroidism Expert Forum
Does anyone have experience with generic Zoloft and levothyroxin(levoth...
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Questions in the Thyroid forum are answered by Mark Lupo, MD. Topics covered include Goiter, Graves Disease, Hyperthyroid, Parathyroid/Calcium Problems, Thyroid Cancer, Thyroid Nodules/Cysts, Thyroiditis, Thyroid & Pregnancy, Thyroid Stimulating Hormone (TSH), Thyroid Tests, and Thyroid Surgery.

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Does anyone have experience with generic Zoloft and levothyroxin(levothyroxine) together

I have been prescribed sevtraline (generic Zoloft) until I adjust to the right dose of levothyroxin (levothyroxine). I am so confused by all this medication and my dr.seems to treat the symptoms . My insurance requires a referral. I think he will eventually refer me to a specialist, however, in the meantime does anyone have experience with taking generic Zoloft and levothyroxin (levothyroxine) together? I take them about 8 hours a part and I am nauseated, with headaches in the middle of the night and early morning, with sleeplessness. Is one interfering with the other? How will I ever know if depression is subsiding from levothyroxin (levothyroxine), if I stay on generic Zoloft? I am wondering if I am in Pandora's Box.
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Yes - zoloft/sertraline can increase hepatic clearance of levothyroxine and in some patients results in increase levothyroxine dose requirements.   It is okay to take sertraline and levothyroxine together, but the thyroid needs to be monitored closer than usual.

Separate from this, you may be having other side effects from a medication or another issue causing symptoms - would talk to your doctor about these.
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