Thyroid Cancer / Nodules & Hyperthyroidism Expert Forum
Insensitivity/intolerance to increased Synthroid doses
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Questions in the Thyroid forum are answered by Mark Lupo, MD. Topics covered include Goiter, Graves Disease, Hyperthyroid, Parathyroid/Calcium Problems, Thyroid Cancer, Thyroid Nodules/Cysts, Thyroiditis, Thyroid & Pregnancy, Thyroid Stimulating Hormone (TSH), Thyroid Tests, and Thyroid Surgery.

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Avatar universal
Insensitivity/intolerance to increased Synthroid doses
Hi,

I've had Hashimoto's for many years and was stabilized comfortably  on 125 mcg of Synthroid until my sudden hyperthyroid episode last spring.  After a swing to hypothyroidism,  I've since been having difficulty tolerating the medication.   I'm currently alternating between 88 and 75 mcg.  I've been increasing it very slowly but struggle with adverse effects i.e. sleep difficulties, every time I up the dose .The target TSH is 1 and it's now slightly under 3..

Why would I suddenly have difficulty tolerating the medication? The dilemma is that if I don't increase the dose, my hypothyroid symptoms persist but increases are problematic.

Any recommendations would be greatly appreciated.

Thank you in advance.,
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97953 tn?1440868992
It is not clear why this happens to some people.  There many be some functioning parts of your thyroid that "acted up" either as a thyroiditis (temporary release of preformed thyroid hormone), Hashitoxicosis (Graves episode causing hyper in a patient who otherwise appears to have hypo due to hashi), or a functioning "hot" nodule.

First approach is to keep adjusting as tolerated, sometimes even switch to a different brand (in this case, try Levoxyl for examle).  As a last resort, some patients want surgery, but this does not consistently solve the problem.
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Avatar universal
Dr. Lupo,

Thanks so much for your help.  I really appreciate it.
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