Is our metabolism based entirely on thyroid hormones or are their other factors that play a role? What makes one person have a fast metabolism and others have slow? I have a good metabolism now. If I exercise regularly, I don't have to worry about what I eat and I never have had an issue with weight. My thyroid functions have always been normal, not hypo or hyper. I am having a thyroidectomy on March 12 for papillary carcinoma and I am worried it may change. Will my metabolism stay the same when I take synthroid?