Thyroid Cancer / Nodules & Hyperthyroidism Expert Forum
Methylselenocysteine for Liver Support
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Questions in the Thyroid forum are answered by Mark Lupo, MD. Topics covered include Goiter, Graves Disease, Hyperthyroid, Parathyroid/Calcium Problems, Thyroid Cancer, Thyroid Nodules/Cysts, Thyroiditis, Thyroid & Pregnancy, Thyroid Stimulating Hormone (TSH), Thyroid Tests, and Thyroid Surgery.

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Methylselenocysteine for Liver Support

Questions: Has anyone tried using the supplement methylselenocysteine for liver support? In your opinion, is it a more effective supplement for hypothyroidism than selenomethionine? (I am currently on 25 mcg of Synthroid for hypo-t. I am using 200mcg of Selenium daily)

The claim is made that methylselenocysteine, an important co-factor of the antioxidant enzyme, glulathione peroxidase is the safest most bioavailable form of selenium commercially available. Dr. Lupo, what is your recommendation?
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There is no definitive data on selenium and autoimmune thyroid disease, only a suggestion that it may help.  The different forms of selenium are synonomous but may vary in bio-availability but studies are limited (ie selenomethione is thought to be more bio-available [ie usable by the body] than selenite).  The JCEM 2002 article from Germany used 200mcg of selenite and showed a decrease in antibodies against TPO.

I am not sure about methylselenocysteine as the the most bio-available.  And selenium in general is a co-factor as you describe.
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Sorry, re subject, I meant to type Thyroid Support for Liver Support
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Thank you for your recommendation. It appears that Selenomethhionine is more bioavailable than Selenium.
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