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Post Thyroidectomy - Anti-TG Ab
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Questions in the Thyroid forum are answered by Mark Lupo, MD. Topics covered include Goiter, Graves Disease, Hyperthyroid, Parathyroid/Calcium Problems, Thyroid Cancer, Thyroid Nodules/Cysts, Thyroiditis, Thyroid & Pregnancy, Thyroid Stimulating Hormone (TSH), Thyroid Tests, and Thyroid Surgery.

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Post Thyroidectomy - Anti-TG Ab

I had a complete thyroidectomy three years ago.  Subsequently, all annual thyroid tests have been normal.  Thyroid antibodies all but disappeared.  As of last week's test, they're elevated (flagged "High") and I don't see the endocronologist until next month.  I have no way of ascertaining whether the increase was gradual (over the last year) or if this reflects a more recent, sudden increase.

Question:  WHERE are thyroid antibodies manufactured (I'm assuming not by the thyroid gland itself?)  And while we're on the topic, where/how are other antibodies produced?

Incidently, I was diagnosed with lupus (SLE) last year and have a positive ANA 1:320 and APL too.   Could the Tg AB impact the ANA titer?   I thought that low ANA titers (i.e., 1:80, 1:160) could be positive with TG Ab but at the higher levels (e.g., 1:320, 1:640), the culprit was most likely NOT connected to the autoimmune thyroid disease.

Thanks!
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The Tg Ab may come and go -- not completely understood -- following trends over time (using the same lab) may be helpful, esp if concerned about catching a thyroid cancer recurrence.  The other antibodies reflect your immune system's tendency to attack the body (autoimmune disease) but the thyroid antibodies don't cause an ANA to be positive in most cases (particularly at higher titres like 1:320).
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Mark Lupo, M.D.Blank
Thyroid & Endocrine Center of Florida
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