Yes, pain can come from your nodular goiter.
At this point, it is important to confirm the cause of the hyperthyroidism as toxic nodule(s) by doing an I-123 uptake/scan (IF TSH still low at least 6-8 weeks after stopping synthroid) and comparing it to the ultrasound. Any nodule that is not "hot" may require FNA biopsy. I-131 treatment or surgery are the treatment options for toxic nodular goiters requiring therapy.
thankyou so much for that very important info..!!!...i did have an uptake scan about a year ago and it did show cold nodules i had an fna and it came back inconculsive..but the dr felt i didnt need another at that time..again thankyou very kindly..i have a better understanding that this severe pain i get is normal and not something else going on...have an awesome day...and thankyou again....b