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How can this happen
Answered by
Mark Lupo, M.D. - Thyroid Nodules, Thyroid Cancer, hyperthyroidism, hypothyroidism, Thyroid Ultrasound
Thyroid & Endocrine Center of Florida Sarasota - FL
Questions in the Thyroid forum are answered by Mark Lupo, MD. Topics covered include Goiter, Graves Disease, Hyperthyroid, Parathyroid/Calcium Problems, Thyroid Cancer, Thyroid Nodules/Cysts, Thyroiditis, Thyroid & Pregnancy, Thyroid Stimulating Hormone (TSH), Thyroid Tests, and Thyroid Surgery.

How can this happen

by Ga7, Sep 22, 2007 02:33PM
I had my thyroids remove completely 25 years ago, well my TSH got up into the 60’s 6 months ago due to generic type synthroid meds.  I was put on 137mcg and then after 6 weeks levels drop to TSH 11.5 with T4 at 1.4, Then dose was moved up to 150mcg. After 4 weeks started to get chest flutters and nervousness.  Went to my cardiologist and he suggested I get my levels checked again, so had my endo do another test and it came back TSH 3.5 and T4 1.8. Well we checked my levels again after two more weeks and the TSH went to 9.1 and T4 1.4 , what could have happened? I take the pill every morning before food at least 45 minutes with full glass of water. He has now up my levels to 175mcg. Is this a good move on his part? He will check levels again in 8 weeks. The same lab is doing all the test.

by Mark Lupo, M.D., Sep 22, 2007 06:14PM
See other recent posts today on this topic as well.......but the change to generic can do this and geting back to optimal TSH sometimes takes time.  There may be an absorption issue -- you are taking the med consistently and in the correct way.  Increasing the dose usually is the right step if the TSH is back up.  Sometimes all these changes will cause some heart palpitations that are temporary.  Would also insist on consistency with a brand -- unless the pharmacist can guarantee that generics will always come from the same manufacturer (not likely, but worth asking).
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