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Hyperthyoid? - Test results confusing!
Answered by
Mark Lupo, M.D. - Thyroid Nodules, Thyroid Cancer, hyperthyroidism, hypothyroidism, Thyroid Ultrasound
Thyroid & Endocrine Center of Florida Sarasota - FL
Questions in the Thyroid forum are answered by Mark Lupo, MD. Topics covered include Goiter, Graves Disease, Hyperthyroid, Parathyroid/Calcium Problems, Thyroid Cancer, Thyroid Nodules/Cysts, Thyroiditis, Thyroid & Pregnancy, Thyroid Stimulating Hormone (TSH), Thyroid Tests, and Thyroid Surgery.

Hyperthyoid? - Test results confusing!

by marctilly, Feb 01, 2007 12:00AM
My recent (1/18/07) blood test results are:

Free T4 1.10 (Range 0.59-2.19 ng/dL)
Free T3 5.32 (Range 2.77-5.27 pg/mL)
TSH     3.09 (Range 0.465-4.680 uIU/mL)

On 3/27/06 my TSH was 1.98

From what I can tell the AACE changed the TSH range to 0.3-3.0 in 2002 but many Drs. and labs are not aware of (or don't agree with?) this.

Finally, the results from a thyroid uptake test (completed yesterday) were:
6 hours - 19%
24 hours - 33.9%

The radiologist indicated that the thyroid pictures showed no abnormalities (nodules, etc.) but that my uptake results indicated a hyperthyroid state.  From what I can tell, this kind of TSH level (normal or high) with elevated free T3 and uptake results is unusual, and perhaps not indicative of a problem with the thyroid directly.

I have some symptoms that are consistent with hyperthyroid and some that are more typical of hypothyroid.

Feedback would be appreciated.

Marc

by Mark Lupo, M.D., Feb 03, 2007 12:00AM
I would watch the Free T3 -- if this continues to elevate and the TSH does not become low, then the concern would be pituitary over-production of TSH (RARE) -- and that would necessitate a brain/pituitary MRI.  This is very rare, and more likely, you may simply run a high normal T3.  The 33.9% uptake at 24h is only slightly high and not diagnostic of hyperthyroidism in this setting.  An elevated blood T3-Uptake (older type of test) would be consistent with hyperthryoidism.  A blood prolactin level would help screen for pituitary issues, but would not be 100% for/against this.

At this time, following the trend will be most important.
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