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Thyroid Cancer, Nodules & Hyperthyroidism (Expert Forum)
Interpretation of Antibody Test, 5908, Please Help!?
Answered by
Mark Lupo, M.D. - Thyroid Nodules, Thyroid Cancer, hyperthyroidism, hypothyroidism, Thyroid Ultrasound
Thyroid & Endocrine Center of Florida
Sarasota - FL
Questions in the Thyroid forum are answered by Mark Lupo, MD. Topics covered include Goiter, Graves Disease, Hyperthyroid, Parathyroid/Calcium Problems, Thyroid Cancer, Thyroid Nodules/Cysts, Thyroiditis, Thyroid & Pregnancy, Thyroid Stimulating Hormone (TSH), Thyroid Tests, and Thyroid Surgery.
Interpretation of Antibody Test, 5908, Please Help!?
by WatchTheWeatherChange22, Mar 04, 2007 12:00AM
28 y/o female, 5'0, 150lbs. diagnosed with "hypothyroid" though "Hashimoto's" is the label frequently used in office by Endo and Rheumatologist. Recently diagnosed with Fibromyalgia after running tests to clear Lupus and other like autoimmune diseases. Not really feeling better yet. In fact, feeling worse.
Medication: 75mcg of Levothyroxine, 5mcg of Cytomel, 1200 units of vitamin per day for the last six months.
My numbers from initial diagnosis, 06/13/05:
165 lbs.
Thyroid Peroxidase(TPOAb): 5908 H IU/ml (0-34 ref. interval
WBC: 11.1 H k103E/uL (4.0-10.5 ref. interval)
TSH: 2.189 uIU/ml (.350-5. 500 ref. interval)
Total Cholesterol: 233 H mg/dL (100-199 ref. interval)
LDL: 163 H mg/dL (0-99 ref. interval)
I restrict foods high in animal fats, and had for the previous two years-- family history of high Cholesterol and other symptoms.
Most recent test, 02/06/07:
157 lbs.
Thyroid Peroxidase(TPOAb):2141 IU/ml (0-34 ref. interval)
TSH: 4.157 uIU/mL (ref. interval .350-5. 500)
(No lipid panel for comparison)
Other abnormal results:
Neutrophils 77 H% (40-74 ref. interval)
Nutrophils (Absolute) 8.5 H k10E3/uL (1.8-7.8 ref. interval)
Questions:
I suspect that my problem is related to the pituitary, something like Cushing's. What exactly counts as "significantly elevated" for Thryoid Peroxidase (TPO) Ab? Should I be tested for Lyme's, Cushing's? I really feel as though there is something bigger happening in my body! What else should I be aware of? Where do I go next? What other tests should be done?
Medication: 75mcg of Levothyroxine, 5mcg of Cytomel, 1200 units of vitamin per day for the last six months.
My numbers from initial diagnosis, 06/13/05:
165 lbs.
Thyroid Peroxidase(TPOAb): 5908 H IU/ml (0-34 ref. interval
WBC: 11.1 H k103E/uL (4.0-10.5 ref. interval)
TSH: 2.189 uIU/ml (.350-5. 500 ref. interval)
Total Cholesterol: 233 H mg/dL (100-199 ref. interval)
LDL: 163 H mg/dL (0-99 ref. interval)
I restrict foods high in animal fats, and had for the previous two years-- family history of high Cholesterol and other symptoms.
Most recent test, 02/06/07:
157 lbs.
Thyroid Peroxidase(TPOAb):2141 IU/ml (0-34 ref. interval)
TSH: 4.157 uIU/mL (ref. interval .350-5. 500)
(No lipid panel for comparison)
Other abnormal results:
Neutrophils 77 H% (40-74 ref. interval)
Nutrophils (Absolute) 8.5 H k10E3/uL (1.8-7.8 ref. interval)
Questions:
I suspect that my problem is related to the pituitary, something like Cushing's. What exactly counts as "significantly elevated" for Thryoid Peroxidase (TPO) Ab? Should I be tested for Lyme's, Cushing's? I really feel as though there is something bigger happening in my body! What else should I be aware of? Where do I go next? What other tests should be done?
Doctor's Answer
by Mark Lupo, M.D., Mar 05, 2007 12:00AM
, Mar 05, 2007 12:00AM
Cushing's is rare - could ask to be tested, but doubt this is the case.
The TSH is too high - dose of levo (or cytomel) should be increased in most cases. If not getting better, then consider additional evaluation.
The TSH is too high - dose of levo (or cytomel) should be increased in most cases. If not getting better, then consider additional evaluation.
Increase in TPO AB does mean that there is something going on w/ an Immune Response!!!!
I spent 1 month in 4 different hospitals being very ill after my GB surgery. What ever is going on find a DR who cares.
I'm 28 and I hobble around like I'm 80. I can't help it, I'm in so much pain. It's clear to everyone around me that something serious is happening. Only those who don't know me well think I have been making excuses. I have been a hard worker and an honest person all my life. I've never been overweight or lazy; I've never been sedentary or weak. All of a sudden I struggle to walk and maintain my balance when I stand up.
I'm afraid. I haven't gotten better in three years of levo therapy. I think it is a pituitary problem.
What do I do? Where do I go?
Columbia is next on my list; I can't seem to find a doctor out here who is willing to consider this beyond a surface level.