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Thyroid Cancer, Nodules & Hyperthyroidism (Expert Forum)
thyroid and xanthones(mangosteen)
Answered by
Mark Lupo, M.D. - Thyroid Nodules, Thyroid Cancer, hyperthyroidism, hypothyroidism, Thyroid Ultrasound
Thyroid & Endocrine Center of Florida
Sarasota - FL
Questions in the Thyroid forum are answered by Mark Lupo, MD. Topics covered include Goiter, Graves Disease, Hyperthyroid, Parathyroid/Calcium Problems, Thyroid Cancer, Thyroid Nodules/Cysts, Thyroiditis, Thyroid & Pregnancy, Thyroid Stimulating Hormone (TSH), Thyroid Tests, and Thyroid Surgery.
thyroid and xanthones(mangosteen)
by Lightfoot, Jul 07, 2007 12:00AM
Had thyroidectomy for cancer 4 years ago at age 50. Am looking at metabolic syndrome in me now. Mangosteen fruit juice has xanthones. The research on this fruit shows some actual effectiveness in decreasing LDL, being cytotoxic to MRSA, is a histamine H1 receptor agonist and a serotenergic receptor blocking substance as well as a 5HAA receptor agonist. I understand that Transthyretin transports T4. It looks like one of the many xanthones binds Transthyretin. Can I take Mangosteen? Would synthroid need adjusted? more or less? Thx.
Doctor's Answer
by Mark Lupo, M.D., Jul 08, 2007 12:00AM
, Jul 08, 2007 12:00AM
The test-tube effects of these various supplement products are touted in marketing but have not been shown to have a clinically significant effect when taken by humans. I have looked into this for mangosteen in the past and saw no human trials proving a benefit.
There is no data regarding the effect on T4 treatment - so if you use these products would retest thyroid levels after about 6 weeks to see if there was an effect that would result in synthroid dose adjustment.
Mangosteen, like nano juice, seems like it would have a great benefit on metabolic syndrome -- but we thought that when looking at test-tube data for Avandia (a major diabetes drug) but now there have been reports of increased cardiovascular death with Avandia.....so, while supplements are generally not likely to do significant harm, there is little proof a benefit -- so the biggest risk is to your wallet.
There is no data regarding the effect on T4 treatment - so if you use these products would retest thyroid levels after about 6 weeks to see if there was an effect that would result in synthroid dose adjustment.
Mangosteen, like nano juice, seems like it would have a great benefit on metabolic syndrome -- but we thought that when looking at test-tube data for Avandia (a major diabetes drug) but now there have been reports of increased cardiovascular death with Avandia.....so, while supplements are generally not likely to do significant harm, there is little proof a benefit -- so the biggest risk is to your wallet.
Member Comments (1)
by uge, Feb 25, 2008 09:45AM
A related discussion, thyroid and Mangosteen was started.
