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540876 tn?1213927297
ALS OR ENDOCRINE?
Hello.

My father-in-law was recently diagnosed with ALS.  Of course we all do not want this to be true, but I am truly skeptical.  He is now 50 as of this year.  Here is a little history that may have some affect:
In the 1970's he was hit over the head with a steel pipe & had brain surgery.
Shortly after that he developed a large fat deposit at the base of his neck on his back.  Doctors have always dismissed this as a "fatty tumor" or other things.  I have recently done some research & realized this is what they call "Lipodystrophy."  This can be a symptom of several other conditions.  Recently he has acquired some new fat deposits in his neck area & around the collar bone.  

Also, about 2 years ago he suffered a heart attack.  Shortly after the heart attack is when he started noticing his legs not working quite right.  He eventually started dragging his feet somewhat & now walks with a cain & has alot of trouble.  It has gotten much worse over time, but recently they did diagnose him with ALS with ONE test.  I believe that they may have just "thrown" out this diagnosis b/c he does not have health insurance.

Also, around the same time the symptoms showed up he quit smoking (b/c of heart attack) & he drinks alcohol on a regular basis.

Before the ALS diagnosis they said they found atrophy in his brain in the area where the surgery in the 70's occured.  Also, he is in alot of pain & has a heightened sensitivity in his feet & has swelling in his legs & feet.  He has also put on a good bit of weight.

Any clue of what else we could have him tested for?
We just did a test for cortisol levels for Cushings.  I suggested a diabetes test.  Any other suggestions?

Thanks,
Bethany
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314892 tn?1264627503
The elderly should always have B12 levels checked as B12 deficiency has a myriad of strange symptoms. The serum b12 level should be ordered as well as MMA and nutritional Homocysteine. The last 2 are important metabolites of b12 and are better indicators of deficiency than b12 alone.

Has he had thyroid levels and all the other usual bloodwork done- CBC, Comprehensive Metabolic Panel, lipids?
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