My 16 yo son was diagnosed with Grave's disease August 07. Started on Tapazole and developed severe itching and hives. Started on PTU Oct. 07. June 08 his liver enzymes were elevated (normal liver enzymes prior to PTU). AST 49, ALT 146, Gamma GT 58. Thyroid ablation July 2008. PTU discontinued Oct. 08. Synthroid started Oct. 08. Consulted liver specialist, ANA titre 1:160, ANCA positive, liver biopsy recommended. Are the increased liver enzymes due to Grave's or the drug therapy (PTU). If it is from Grave's, how and why. If it is from the PTU shouldn't it reverse after the PTU was stopped. How long do you have to be off PTU to see if it is from the drug. A liver biopsy is recommended. How will this help. What can this procedure show to aid in lowering his high liver enzymes. Can this be reversed and if so what treatment is recommended. Is this an ongoing problem for the rest of his life. Is this auto-immune hepatitis.