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Mind you, I have only been back on meds a whopping two days. Synthroid 150. But I had this side affect when I was on synthroid before. I get up, take my medicine and wait the prescribed 1/2 hour to an hour before I eat something. About 20 minutes after I take the pill, I get this hollowed out feeling. It's not like an "oh, I'm a bit hungry" It's a totally hollowed out and almost painfull feeling right below my sternumSternum - view of the outside (anterior). I get jittery and antsy. Then I eat, it gets better and about an hour later it happens again. when I eat cereal for breakfast, it's really bad until I eat lunch. This a.m. I tried peanut butter on bread and the hollowed out feeling hung around until about 9:30 a.m. and got gradually better thru the day. After I eat lunch, it pretty much goes away completely. I have yet to find the magicMagic bullet thing that makes it stop in the early hours.