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I too have Hashimoto's, I have dealt with the prolonged constipation. I have found that having a Fiber One bar helps, although it makes you bloated. However, the last three weeks I have been having loose stool. Perhaps it's uncomfortable because I am so used to being constipated. Is it normalNormal saline flush to be going 3-4 times a day? I wanted to comment on the fact that you have noticed a lack of appetite with your Hashi's. I have also encountered this. Although, there is no weight-loss involved. I can go the entire day without eating sometimes. I don't though. My friends think it is strange that I only eat once or two small meals a day. It is not uncommon for me to not eat anything until 3 or 4pm and be satisfied the rest of the eveningEvening primrose Evening primrose oil. I think this contributes to a slow metabolism which prevents me from weight-loss.