What happens to the body when TSH levels reach extreme levels (>500)? I know about fatigue and depression but I am curious about what happens to the actual mechanics of the body. Thank you for your time.
Damages fron symptoms of hypothyroidism will depend on how long hypo before being diagnosed and treated, and how severe the hypothyroidism.
The most dangerous effects on the body would be:
Myxedema coma - life-threatening complication of untreated hypothyroidism.
Heart - Thyroid hormone is very important for normal cardiovascular function, so when not enough thyroid hormone is present neither the heart nor the blood vessels function normally. In hypothyroidism the heart muscle is weakened in both its contraction phase, and also its relaxation phase. This means that the heart cannot pump as vigorously as it should, and the amount of blood it ejects with each heart beat is reduced. In addition, because the heart muscle does not relax normally in between heart beats, a potentially serious condition called diastolic dysfunction may result. Furthermore, hypothyroidism reduces the amount of nitric oxide in the lining of the blood vessels, causing them to stiffen.
Cholesterol and Lipid Levels - Hypothyroidism is significantly associated with unhealthy lipid levels.
High Blood Pressure (Hypertension). Hypothyroidism - may slow the heart rate to less than 60 beats per minute, reduce the heart’s pumping capacity, and increase the stiffness of blood vessel walls.
Homocysteine - Studies are also finding that hypothyroidism is associated with elevated levels of homocysteine, an amino acid that is increasingly becoming a major suspect in heart diseases.
Iron deficiency anemia.
Glaucoma. Some research has associated hypothyroidism with an increased risk for glaucoma.
Headache. Hypothyroidism may also worsen headaches in people predisposed to them.
Depression. Depression is common in hypothyroidism and can be severe
Mental and Behavioral Impairment. Untreated hypothyroidism can, over time, cause mental and behavioral impairment and, eventually, even dementia.
Goiter - may cause the thyroid gland to become enlarged and form a goiter (termed a "compensatory goiter")
Hypothyroidism is also commonly associated with iron deficiency anemia and respiratory problems. Some research has associated hypothyroidism with an increased risk for glaucoma. Hypothyroidism may also worsen headaches in people predisposed to them.
There are other health consequences that can be dealt with and heal from, but the above is the more serious.
Copyright 1994-2016 MedHelp International. All rights reserved.
MedHelp is a division of Aptus Health.
This site complies with the HONcode standard for trustworthy health information.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.