Hi, I need your input! I am an African-American female, 47, 5'3", 244 lbs., in good health. (I have fibroid tumors, I have heavy menstrual periods, I've been anemic for several years, and I developed asthma @ 3 years ago.) In 4/07, I had my thyroid removed because a (benign) tumor/goiter was partially obstructing my windpipe. Since the surgery, I've gained 11 pounds and developed shortness of breath and fatigue. I had a blood test last week. The T4, Free level is 1.5; the TSH w/free T4 rfx, TSH, 3rd generation level is .87; the total iron level is 25; the transferrin saturation level is 8. I currently take .175 mg of Synthroid. Should I ask my endocrinologist for an increase in the dosage? Or do you think that the fatigue is primarily gynecological in nature, and that I should look into having the fibroids removed? I have been trying to lose weight and exercise, but the tiredness interferes with my efforts. I value your opinion, and look forward to your response. Thank you!