I've been dealing with major issues related to fatigue, joint pain, mouth sores, etc for at least 8 years. Three years ago my ANA was 1:1280 but all other blood work was normal (despite extreme fatigue, etc.) I was referred to a Rheumatologist who said I had undifferentiated connective tissue disease, he tried me on Plaquenil but it didn't really help so he took me off of it and then told me to see a psychologist. My ANA was checked again and it was 1:320. After a year of this kind of "it's all in your head" treatment, I gave up on going to the doctor. Two years later my fatigue is worse than ever, I constantly feel like I'm in a fog and find it very difficult to concentrate. I decided to go to a new doctor, and had a bunch of blood work done last week. The following results were abnormal: TSH: 9.08 (.45-4.5), Vitamin D: 22.4 (32-100), Neutrophils: 34 (40-74), Absolute Neutrophils: 1.4 (1.8-7.8), Lymphs: 48 (14-46). My overall WBC is 4.1 (4.0-10.5). A complete ANA panel was pulled with all results <.2 except for Antichromatin Antibodies: .8 (.0-.9). I did have a slightly low Vitamin D result 2 years ago and my TSH has been on the high side 2 times over the past 4-5 years but never higher than 6.3, since it always fluctuated back to normal the doctors didn't think it was an issue. I am 37 years old, and if anything, I'm more underweight than overweight which seems to be opposite for hypothyroidism. I currently don't feel sick and I don't have a fever, I'm just very tired (sleeping 12-15 hours per night and still struggling to get out of bed) and unable to focus on anything. I have a follow up with my Primary Care doc as well as my Rheumatologist in a couple of weeks. I realize that these results can cause many things, but given the combination, I was wondering if you could lend some insight.