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Hormone and Thyroid Help Please!

First of all, I would appreciate anyone who could assist with my pieces of the puzzle!  For the last several months I feel like I am crying at the drop of a hat, am more moody than usual and am irritated by most people and events.  I feel tired most of the time yet I cannot sleep at night.  

I am known to be somewhat forgetful, but feel more so lately.  I have no sex drive.  I have had in the past and continue to have problems with constipation.  

I was hoping my bloodwork from my yearly physical would be the light at the end of the tunnel, but my doctor said the results were fine.  I was sure it was something hormone related and would appreciate any input.  My doctor thinks my symptoms are from sleep deprivation.  I have dealt with depression for 10 years now and know this is more but I don't know what.

Stats:
33 yo female
172 lb, 5'4"
Mirena IUD

Estrogen Total 691 pg/mL
(no range given. I have not menstruated for two years due to Mirena)
Progesterone 0.8  ng/mL

TSH 4.16  (0.27 - 4.20) uIU/mL

Cholesterol 164 (140 - 199) mg/dL
Triglyceride 81 (0 - 149) mg/dL
HDL 50 (>=40 -)   mg/dL
LDL 98 mg/dL
VLDL 16 (0 - 30) mg/dL
Chol/HDL Risk Ratio 3.28 (0.00 - 5.00)
Fasting Yes  

Glucose 87 (70 - 100) mg/dL
BUN 20 (5 - 20) mg/dL
Creatinine 0.74 (0.50 - 1.30) mg/dL
BUN/Creatinine Ratio 27.0 (10.0 - 25.0)  

I was not tested for T3 or T4 that I've been reading about as I asked for progesterone and estrogen testing - thyroid was not something I considered.

Thanks for any help or insight.

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649848 tn?1534633700
COMMUNITY LEADER
You should specifically ask for the thyroid hormone tests, Free T3 and Free T4 (be sure to specify FREE).  With your TSH higher than it should be, there's a good chance that your actual thyroid hormones are lower than you need them.

As Red_Star pointed out, the most common cause of hypo is Hashimoto's, so it would be good to get tested for the antibodies.  If you have Hashimoto's, you can expect your thyroid to decline over a period of time.

I'd also recommend that you get tested for vitamin B12 (deficiency can cause extreme fatigue, plus other symptoms), vitamin D, calcium, magnesium and selenium.  Deficiency of any of these vitamins/minerals can cause hypo-like symptoms.
Helpful - 0
1756321 tn?1547095325
I didn't word that last sentence well but i mean you may have Hashimoto's thyroiditis concurrently with estrogen dominance. :)
Helpful - 0
1756321 tn?1547095325
To add, the American Association of Clinical Endocrinologists (AACE) guidelines for TSH is 0.3 - 3.0 mU/L.  The most common cause of hypothyroidism is Hashimoto's thyroiditis so testing for thyroid antibodies - thyroid peroxidase (TPOAb) and thyroglobulin antibodies (TgAb) may reveal this autoimmune disease as well as estrogen dominance.  
Helpful - 0
1756321 tn?1547095325
Your estrogen levels are way too high. Total estrogen normal reference range: Day 1 - 10: 61 - 394pg/mL, Day 11–20: 122–437 pg/mL; Day 21–30: 156–350 pg/mL.  

High estrogen leads to excessive production of thyroid binding globulin (TBG).  Although there are enough thyroid hormones in the blood, they are not taken up by the body's cells as they are inactivated by TBG.  In other words, thyroid labs are in range but you have signs of low thyroid function. That said, your TSH is higher than it should be. You may find all your symptoms resolve when correcting estrogen dominance.

***

From the Natural Progesterone Advisory Network article "Symptoms of Estrogen Dominance - Are you a Candidate for Natural Progesterone?" Natural Progesterone Advisory network...

"If you experience any of the following symptoms associated with estrogen dominance, or are being treated for any of the medical conditions listed, supplementing with natural progesterone cream may help:

• Acceleration of the aging process
• Adrenal exhaustion
• Allergy symptoms (asthma, hives, rashes, sinus congestion)
• Autoimmune disorders (lupus erytherometosis, thyroiditis, possibly Sjögren’s disease)
• Breast cancer
• Breast tenderness
• Cervical dysplasia
• Cold hands and feet as a symptom of thyroid dysfunction
• Decreased sex drive
• Depression with anxiety or agitation
• Dry eyes
• Early onset of menstruation
• Endometrial (uterine) cancer
• Endomemtriosis
• Fat gain, especially around the abdomen, hips, and thighs
• Fatigue
• Fertility
• Fibrocystic breasts
• Fibromyalgia
• Foggy thinking
• Gallbladder disease
• Hair loss
• Headaches
• Hypoglycemia
• Hysterectomy (ovaries removed)
• Increased blood clotting (increasing risk of strokes)
• Infertility
• Irregular menstrual periods
• Irritability
• Insomnia
• Magnesium deficiency
• Memory loss
• Mood swings
• Osteoporosis
• PMS
• PCOS
• Post-Natal Depression
• Premenopausal bone loss
• Premature Births
• Prostate cancer (men)
• Protection against reproductive cancer
• Sluggish metabolism
• Thyroid dysfunction mimicking hypothyroidism
• Tubal Ligation (tubes tied)
• Uterine cancer
• Uterine fibroids
• Water retention, bloating
• Zinc deficiency"
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649848 tn?1534633700
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