Thyroid Disorders Community
Hyperparathyroidism?
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This patient support community is for discussions relating to thyroid issues, goiter, Graves disease, Hashimoto's Thyroiditis, Human Growth Hormone (HGH), hyperthyroid, hypothyroid, metabolism, parathyroid, pituitary gland, thyroiditis, and thyroid Stimulating Hormone (TSH).

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Hyperparathyroidism?

Hello! I am 34 (almost 35). Last year, right before I turned 34 I was diagnosed with a very rare, staghorn, kidney stone. Because it was so big, they had to do 2 surgeries. I keep showing white blood cells in my urine, but the cultures come back negative. I have already developed a new stone, though a small one. My surgery was just 6 months ago.   I'm in the process of getting my blood work from all my doctors, because I think I have hyperparathyroidism. Because my Parathyroid level was low last week (10.0) my doctor's say I can't have it. My calcium was 9.8 and my ionized calcium was 5.55. I was not fasting on any of this blood work. I have almost every symptom of this. I know in August, my serum calcium was 9.2, June 8 (2 weeks before my surgery) my calcium was 7.9. My kidney stone was 100% calcium deposit stone. I have been on parathyroid.com non stop, and I firmly believe I have this.  But, can anybody offer me advice?? I read this is deadly if left untreated, and I have 4 boys...I want to find out for sure if I have this. PLEASE SOMEBODY HELP!
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One study concludes the diagnosis of primary hyperparathyroidism should be pursued despite suppressed or low-normal serum intact PTH levels after carefully excluding other causes of hypercalcaemia.  "Very low or undetectable intact parathyroid hormone levels in patients with surgically verified parathyroid adenomas." PMID: 18284640.

Causes of hypercalcaemia:

Most common (malignancy and primary hyperparathyroidism account for 90% of hypercalcemic patients):

* Primary hyperparathyroidism

* Malignant disease:
- PTH-related protein (carcinoma of lung, esophagus, head and neck,
renal cell, breast, ovary, and bladder)
- Ectopic production of 1,25-dihydroxyvitamin D (lymphoma)
- Lytic bone metastases (multiple myeloma, hematologic
malignancies and breast carcinoma)
- Other factor(s) produced locally or ectopically

Uncommon:

* Endocrine disorders:
- Thyrotoxicosis

* Granulomatous diseases:
- Sarcoidosis
- HIV

* Drug-induced:
- Vitamin D
- Thiazide diuretics
- Lithium
- Estrogens and antiestrogens
- Androgens (breast cancer therapy)
- Aminophylline
- Vitamin A
- Aluminum intoxication (in chronic renal failure)

* Miscellaneous:
- Immobilization
- Renal failure (acute and chronic)
- Total parenteral nutrition

Rare:

* Endocrine disorders:
- Pheochromocytoma
- Vasoactive intestinal polypeptide-producing tumour
- Familial hypocalciuric hypercalcemia

* Granulomatous diseases:
- Tuberculosis
- Histoplasmosis
- Coccidioidomycosis
- Leprosy

* Miscellaneous:
- Milk-alkali syndrome
- Hypophosphatasia
- William’s syndrome
- Rhabdomyolysis (presentation is usually preceded by a hypocalcemic
state)
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