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Low Serum Iron, TIBC &Ferritin, what's wrong?
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Low Serum Iron, TIBC &Ferritin, what's wrong?

Hi,
I just have my serum iron, TIBC tested to find out the reasons of low Ferritin, following is the result

Serum Iron 8.8 (9.0-27.0) umol/L
TIBC 38.1 (40.8-76.6) umol/L

And my Ferritin tested one month ago was also low Ferritin 34.2 ug/ml (6-159), VB12 245pmol/l (156-672)

So What type of Anemia I have? Normally, if someone is lack of iron, he/she would not have lower level of TIBC, but high level, right? What's wrong with me and why?

Thanks
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6 Comments Post a Comment
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523918_tn?1244553431
It looks like you have low iron intake,your ferritin could be much higher, but you can't evaluate an anemia with only those values. should test also:
Full blood count (FBC)
Haemoglobin (MCH)
Hematocrit
Retyculocites (%)
Blood film (morphology of cells)
folic acid
Hemoglobin electrophoreses
You should test also for transferrin instead of TIBC, it's more accurate for anaemia evaluation. But a low TIBC or transferrin may occur if you have hemochromatosis (you don't because your iron in serum is low), certain types of anemia in which iron accumulates, malnutrition, inflammation, liver disease, or nephrotic syndrome (a kidney disease that causes loss of protein in urine).
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Avatar_f_tn
The following is what I had tested one month ago

MCV 93.1 (82.0-92.0)
MCH 31.4 (27.0-31.0)
MPV 8.2 (8.5-11.8)
RBC 4.05 (3.50-5.50),
PCV is 37.70(35.00-50.00)
Hgb is 127( 110-150)
folic acid (folate) >24 ng/l (3.2-6.4)
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523918_tn?1244553431
I think you need a more study of your blood, looks like you don't absorb much iron may be because of low Vit B12 (242 is normal but you can have higher), I would test for antibodies that cause pernicious anaemia too. Don't forget the tranferrin (it gives information about how your liver is working), retyculocites, blood film and hemoglobin electrophoreses. You should also test white blood cells and platelets counts.Your folic acid is high, no problem isn't toxic (so it isn't the reason).
Are you taking any medication?
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Avatar_f_tn
I am hypoT and taking T4 hormone now.
WBC 5.9 (4.0-10.0)
platelets counts 143 (100-300)

the tranferrin = TRF=TIBC×0.70, so I don't think it is necessary to have it tested

For pernicious anaemia, the TIBC would be high, so I don't think it is apply to me.

for other indicator, I don't know the details about it


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523918_tn?1244553431
With TIBC you measure transferrin saturation. Total iron binding capacity (TIBC) is an indirect measure of transferrin.I prefer the transferrin test (direct test).  Because transferrin is made in the liver, TIBC and transferrin will also be low with liver disease. Lower-than-normal TIBC may mean:
Cirrhosis; Hemolytic anemia; Hypoproteinemia ;Pernicious anemia ;Sickle cell anemia ;Inflammation ;Malnutrition ;Liver disease ;  hyperthyroidism.

In iron overload states TIBC usually is high, in your case with low iron in serum and low ferritin you should also have high TIBC and you don't have, so something is not working correctly.....But with your values you have low iron in your blood.......I would repeat everything.
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Avatar_n_tn
hi..if my serum iron is 2.0 and my hb is 9.0..what does it means???
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