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Low TSH and High T4

Hello,

I'm a lady of 24 years old. I have been taking 75mcg of Thyroxine daily for past 1 year as Doctor advised.
Last year's blood test result was:
T3      0.38ng/ml     (0.7-2.0 ng/ml)
T4      6.9mg/dl       (4.5-12.0mg/dl)
TSH    22.90mIU/ml (0.30-4.5 mIU/ml)

He also told that i have soft goiter.

When I tested the blood last week, the results were:
T3      105ng/dl         (60-181 ng/dl)
T4      13.6mg/dl       (4.5-12.0mg/dl)
TSH    0.03mIU/ml    (0.30-4.5 mIU/ml)

Earlier I was told hypothyroidism, now its hyperthyroidism. Anyone please advice whats going through and what to do next? Do I need to cut short 75 mcg dosage of thyroxine?
Best Answer
649848 tn?1534633700
COMMUNITY LEADER
If the lab test doesn't say "Free T3 or "T3, Free" or contain either Free or F, then it's Total T3; same goes for T4.  Unfortunately, the tests of Total T3 and Total T4 are considered obsolete, because much of the Total T3 and Total T4 is bound by protein and is unusable.

Your T3 is only at 37% of the range and rule of thumb for  Free T3 is for it to be in the upper half to upper third of its range.  Since your doctor is only testing Total T3, we don't know exactly what your Free T3 is.

Can you talk to your doctor and ask for the Free T3 and Free T4 tests?  

Once a person is on thyroid medication, it's not unusual for TSH to be suppressed.  My own TSH has been at < 0.01 - 0.01 for the past 6 yrs and I haven't been hyper.

Your labs indicate that you may not be converting FT4 to FT3, but without those labs, we really can't tell what's going on.  Your symptoms, on the other hand, "could" indicate over medication.

Have you actually lost weight or are you just a small person?  Not everyone gains weight when they are hypo.  I'd also wonder about the eye problems - what problems are you having?  The menstruation issue is a hypo symptom, as is the dry skin and memory issue.

You could talk to your doctor about possibly alternating 50 mcg with 75 mcg for an average of 62.5 mcg/day and see if that helps, but I'm afraid you will simply go more hypo.   It would appear that you might not be converting the T4 to T3 properly and might need to add a source of T3.  This can be done by adding a small dose of cytomel or generic T3 or by switching to a desiccated med that contains both.  Since you're already on the thyroxine, it might be easier to just add T3 med.

Just  out of curiosity -- would you by any chance be in U.K.?
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Avatar universal
Thank you so much for the reply :) It means a lot 4 me.

And regarding your questions, yes- I'm a small person and i haven't gained much weight after diagnosed as hypo. I'll test regarding the Free T3 and T4 and will let you know the status. By eye problem, i mainly meant that i have headache and pain near eyes sometimes, as like migraine.It happens when I'm exposed to light I think. I don't know if that is really a symptom for this.

And I'm right now in India. Sometimes i may travel to UK after few months as my fiance is working in UK :) Actually your curiosity was a surprise for me.. Are you at UK?
Helpful - 0
Avatar universal
listen to barbie135. She knows.  Just let me underline that you need to know your FREE T3. That's the one that your body needs
Helpful - 0
Avatar universal
I dont know much about Total and Free T3/T4 results. My first report says its Total T3 and T4. Second report says its Serum T3 and T4. Are these same?

Symptoms which I'm experiencing are mainly menstruation problems( occurs only once in two months, or sometimes 3 months), headache,low weight, eye problems, dry skin, weak in memory power at times etc.

Do I need to continue taking daily dosage of 75 mcg now?
Helpful - 0
649848 tn?1534633700
COMMUNITY LEADER
You're  not hyper just because your TSH is low.  TSH is a pituitary hormone and once one is on thyroid medication, it often becomes irrelevant.  

Is that Total T4 and Total T3 or Free T4 and Free T3?  They aren't the same tests and Total T4 and Total T3 are not very useful, because approximately 90-95% of the T4 and T3 will bound by protein and are unusable.

That said, while your T4 is high, your T3 is very low in the range, indicating that you aren't converting the T4 to T3.  Free T3 is the hormone that's used by the individual cells.

What, if any, symptoms do you have?  
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