Low to normal TSH & High TPO, and recurrent pregnancy loss

[njkasia]

Hi,

I recently received thyroid profile testing results, prompted by previously results: low TSH results of 0.03 MIU/L (with normal T3 & normal but slightly low T4). This follow-up testing resulted in normal TSH (2.50 UIU/L), with normal, but slightly lower FreeT4 & T4 (0.89 ng/dL & 5.58 ug/dL). Thyroid Peroxidase Antibody testing was performed (1st time) & results are 1247 U/mL (well above the <60 U/mL range). My WBCs & Abso Neutrophils are slightly low (below range).  My cholesterol results are total  (231), Tri (99), LDL (110), and HDL (101).
My history includes a miscarriage, followed by 3 years of no pregnancies, followed by another miscarriage, and most recently my son being born still at 26 weeks.  I have recently tested weakly positive for lupus, heterozygous for C677t mutation, negative for Anti-cardiolipin Antibody & Factor V Leiden. Homocysteine levels (non-fasting) are normal. My first concern is for carrying a healthy pregnancy to term - what do my results indicate?

[njkasia]

Hi Tamra,

Thank you for your comments. Unfortunately I'm probably comparing apples with oranges. The 'low' TSH results were from New York University Hospital, where my T3 total & Free T4 were normal (I'm pretty confident in their stds). My my 'normal' TSH results, however, were from another facility (possibly with an antiquated testing standard). I live overseas & almost everything is sent to the US for testing.  But you're absolutely right - this needs to be sorted out (it's like a battle to convince the medical community of this!)

Thank you for the website - do you know who establishes this 'top doctors' list? It sort of looks to me like it's from patients....

thanks!
cathy

[TamraW]

Your high TPO, low FT4/FT3 and HIGH TSH (2.5 is NOT normal) indicates Hashimoto's Disease.

Average TSH should really be a 1.1. Your doctor is using old lab standards for TSH. Your FT4/FT3 is low. This causes miscarriages and early term babies. This can also cause babies to be born with lower IQ levels.

I have Hashimoto's Disease. I take a thyroid hormone to bring my TSH down, and my FT3/FT4 up. I will always have Hashimoto's antibodies, but I at least have better thyroid levels thanks to the medication.

Plenty of women with Hashi deliver healthy, normal babies. BUT YOU NEED TO BE ON THE CORRECT DOSAGE OF THYROID HORMONE FIRST!!! Your doc should start you out on a low dose. It make take several months to reach your optimum levels.  Most of us feel better when our FT4/FT3 is on the higher end of normal. I wouldn't suggest trying to get pregnant until your FT3/FT4 levels are up.

Find a good endo who can treat your disease, one who specializes in thyroid, NOT DIABETES. I don't know about the Lupus test. Many people test positive for Lupus antibodies and DON'T have it. Doctors must run other tests for a positive diagnosis.

Here's a website that lists recommended endos if you live in the states:
http://www.thyroid-info.com/topdrs/

:) Tamra