Need some help understanding my latest lab results.

[Flipfloppie]

I just received my latest lab results and I’m so confused.  My levels are all over the place and I’m so tired of feeling this way.

I’m open to any suggestion.

Firstly let me start at the beginning.  I was diagnosed with Hashimoto’s in December 2014.  I’ve been gluten free since October 2014 and dairy free since February 2016.

I’m taking Nature-Throid 2GR (130mg) and Liothyronine 25mcg (1/2 in morning and other half 6-8 hrs later) and LDN 4.5mg since November 2016.

TSH - 0.055 (0.350 – 5.500)
FREE T3 - 2.20 (2.30 – 4.20)
FREE T4 – 0.7 (0.9 – 1.8)
ANTI-THYROGLOBULIN - > 500 ( 4000 (<115)
ANTI-THYROPEROXIDASE – 274 (<60) -- Previous 131 (<34)
VITAMIN D – 20.4 (30 – 100)
FOLIC ACID SERUM – 7.0 (8.7 – 24.0)
FERRITIN – 39.8 (10 – 291)
GLUCOSE – 108 (70 – 99)
INSULIN – 10.7 (1.7 – 31.0)
AC1 – 5.5 (NORMAL HBA1C <5.7%)
PROGRESTERONE – 0.23
ESTRADOIL – 213

Am I in for another autoimmune disease? I'm so scared…

Thanks….

[Flipfloppie]

Thank you so much. Im supplementing vitamin d but my count just dont want to go up. I will increase dosage more. I have taken progesterone before but it messed my cycle up and i ended up in the ER with Menorrhagia. I have been told to consider a hysterectomy. I only have 9 or less periods a year for the last 6 or so years.
I guess im just tired of feeling off.

[gimel]

From the result and the ranges, it is easy to see that your Progesterone is way low, unless you are postmenopausal.  If postmenopausal, then your Estradiol  is way high.  At any rate it appears that you are estrogen dominant, which has significant effects on the thyroid system.  Estrogen dominance causes an overload of TBG, which binds even more of the serum T4 and T3, leaving little Free T4 and Free T3.  Your doctor should check for that possibility by testing TBG,  Total T4 and Free T4.  If an overload of TBG is not the problem then you are not absorbing the thyroid med well and need to just increase the dosages.

And don't forget that you need to supplement as needed to optimize your Vitamin D to at lest 50, and your ferritin to at least 70.

[gimel]

I need to know the units of measure shown on the lab report for the Progesterone and Estradiol

[Flipfloppie]

PROGESTERONE 0.23
Follicular < 1.54 ng/ml
Luteal 7.45 - 15.4 ng/ml
Postmenopausal <0.20 ng/ml

[Flipfloppie]

ESTRADIOL 213.2
Follicular 19.5 - 144.2 pg/ml
Midcycle 63.9 - 356.7 pg/ml
Luteal 55.8 - 214.2 pg/ml
Postmenopausal 0.0 - 32.2 pg/ml

[gimel]

AAARRRGGGG!  I wrote a long reply and somehow I lost it.  Anyway I'll try to recall it all.

You have a lot of symptoms that are frequently related to hypothyroidism. The cause for those is your low levels of Free T4 and Free T3 which are even below the ranges, which are too broad anyway.  Many of our members say that they need Free T4 to be at least mid-range, and Free T3 to be in the upper half of its range, and adjusted from there as needed to relieve hypo symptoms, without causing any hyper symptoms.

A good thyroid doctor will treat a hypothyroid patient clinically by testing and adjusting Free T4 and Free T3 as needed to relieve symptoms without being influenced by resultant TSH levels.  Symptom relief should be all important, not just test results. I say that about TSH because many times a doctor erroneously believes that a suppressed TSH like yours means that the patient is hyperthyroid and that medication must be reduced.  In reality the patient is hyper only if having hyper symptoms due to excessive levels of Free T4 and Free T3.  Since your TSH is suppressed, apparently your doctor knows this and has not reduced your med dosages.  That is a good sign about the doctor.

With your med dosages I would have expected that your Free T4 and Free T3 levels would be higher.  It may be that your body is just not absorbing the meds.  Another possibility is the your Thyroxine Binding Thyroglobulin (TBG) is high.  High levels of TBG will bind up T4 and T3 resulting in less Free T4 and Free T3.  One of the causes for high TBf is a low ratio of Progesterone to Estradiol.  In order to assess that  please post the measurement units shown on the lab report for those.

At any rate you need to get your Free T4 and Free T3 levels high enough to relieve symptoms.  In addition, your Vitamin D is much too low.  It needs to be at lest 50.  Your ferritin is also low.  It needs to be at least 70.  So you need to supplement to optimize those.  You should also test for B12, and supplement as needed to optimize.  B12 should be in the upper end of its range. B12 deficiency can contribute to fatigue.  

If you will post the requested measurement units shown on the lab report I will figure out the ratio and report back  

[Flipfloppie]

Hi gimbal, thank you so much for taking time to answer my question.

My vitamin b12 level is 761 (193-986)
Methymalonic Acid serum (MMA Serum/plasma, b12) 0.13 (0.00 - 0.40)

PROGESTERONE – 0.23
follicular  4000 (<115)
ANTI-THYROPEROXIDASE –  131 (<34)
I also tested positive for MTHFR C677T

[Flipfloppie]

Sorry the message got all scrambled. Here its again.

My vitamin b12 level is 761 (193-986)
Methymalonic Acid serum (MMA Serum/plasma, b12) 0.13 (0.00 - 0.40)

PROGESTERONE – 0.23
follicular  4000 (<115)
ANTI-THYROPEROXIDASE –  131 (<34)
I also tested positive for MTHFR C677T

[Flipfloppie]

Not sure why the message gets scrambled.

My vitamin b12 level is 761 (193-986)
Methymalonic Acid serum (MMA Serum/plasma, b12) 0.13 (0.00 - 0.40)

PROGESTERONE – 0.23
Follicular  4000 (<115)
TPO –  131 (<34)

I also tested positive for MTHFR C677T

[gimel]

?

[Flipfloppie]

Im mainly tired, brain fog, weight gain, hair loss, always sleepy, wake up tired, disconnected, muscle and bone aches (on and off), headaches, acne (adult), to mention just a few.

[gimel]

Before discussing further, please tell us about any symptoms you have.  AS an indicator  of thyroid status, symptoms are even more important than blood test results.