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This is going to be an ongoing issue because it is a side effect. The only thing you can truly do to end the itching is to switch meds again or as you said do the RAI. I had PTU and my problem was that I itched & my heart raced. Unfortunately, these are th options. I work in the medicine field, & have been dealing with a thyroid condition for better than 10 years. It's soooooo frustrating & medicine doesn't always make sense. I wish you nothing but the best in your battle. Happy Holidays!